Document Detail

Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs.
MedLine Citation:
PMID:  21704565     Owner:  NLM     Status:  MEDLINE    
Relationships between reproductive hormone levels, bone turnover marker levels, bone mineral density, and rates of bone loss were evaluated in premenopausal women with epilepsy taking enzyme-inducing antiepileptic drugs (EIAEDs: phenytoin or carbamazepine) or lamotrigine. Calciotropic and reproductive hormone levels, bone turnover marker levels, and bone mineral density were measured at baseline and 1 year. Bone mineral density did not differ between groups. Serum calcium (P<0.001) and estrone (P<0.001) levels were lower in the EIAED group. Sex hormone-binding globulin levels were higher (P<0.001) and percentage free estradiol levels were lower (P<0.001) in the EIAED group. We detected no relationship between bone mineral density change and calciotropic hormone or bone turnover marker levels. Women with higher sex hormone-binding globulin and lower free estradiol levels sustained more bone loss at the total hip (P=0.04 and P=0.02) and a trend toward more bone loss at the lumbar spine (P=0.07 and P=0.08). These findings suggest that lower estrogen levels may contribute to bone loss in premenopausal women with epilepsy.
Alison M Pack; Martha J Morrell; Don J McMahon; Elizabeth Shane
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-25
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  21     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-15     Completed Date:  2011-12-12     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Neurology, Columbia University, New York, NY, USA.
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MeSH Terms
Anticonvulsants / pharmacology,  therapeutic use*
Bone Density / drug effects
Carbamazepine / pharmacology,  therapeutic use*
Epilepsy / blood*,  drug therapy
Estradiol / blood*
Phenytoin / pharmacology,  therapeutic use*
Triazines / pharmacology,  therapeutic use
Vitamin D / blood*
Grant Support
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 1406-16-2/Vitamin D; 298-46-4/Carbamazepine; 50-28-2/Estradiol; 57-41-0/Phenytoin; U3H27498KS/lamotrigine

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