| Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs. | |
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MedLine Citation:
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PMID: 21704565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relationships between reproductive hormone levels, bone turnover marker levels, bone mineral density, and rates of bone loss were evaluated in premenopausal women with epilepsy taking enzyme-inducing antiepileptic drugs (EIAEDs: phenytoin or carbamazepine) or lamotrigine. Calciotropic and reproductive hormone levels, bone turnover marker levels, and bone mineral density were measured at baseline and 1 year. Bone mineral density did not differ between groups. Serum calcium (P<0.001) and estrone (P<0.001) levels were lower in the EIAED group. Sex hormone-binding globulin levels were higher (P<0.001) and percentage free estradiol levels were lower (P<0.001) in the EIAED group. We detected no relationship between bone mineral density change and calciotropic hormone or bone turnover marker levels. Women with higher sex hormone-binding globulin and lower free estradiol levels sustained more bone loss at the total hip (P=0.04 and P=0.02) and a trend toward more bone loss at the lumbar spine (P=0.07 and P=0.08). These findings suggest that lower estrogen levels may contribute to bone loss in premenopausal women with epilepsy. |
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Authors:
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Alison M Pack; Martha J Morrell; Don J McMahon; Elizabeth Shane |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-25 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 21 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-15 Completed Date: 2011-12-12 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Columbia University, New York, NY, USA. ap390@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / pharmacology, therapeutic use* Bone Density / drug effects Carbamazepine / pharmacology, therapeutic use* Epilepsy / blood*, drug therapy Estradiol / blood* Female Humans Phenytoin / pharmacology, therapeutic use* Triazines / pharmacology, therapeutic use Vitamin D / blood* |
| Grant Support | |
ID/Acronym/Agency:
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1K23AR053113/AR/NIAMS NIH HHS; K23 AR053113-05/AR/NIAMS NIH HHS; RR00645/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Triazines; 1406-16-2/Vitamin D; 298-46-4/Carbamazepine; 50-28-2/Estradiol; 57-41-0/Phenytoin; 84057-84-1/lamotrigine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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