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Normal values of left-ventricular mass: echocardiographic findings from the PAMELA study.
MedLine Citation:
PMID:  22495137     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND AND AIM: : Upper reference values of echocardiographic left-ventricular mass in the European population are based on scanty data mostly derived from northern European population-based samples. Furthermore, data in apparently healthy populations have included individuals with conditions affecting left-ventricular mass such as obesity, diabetes and masked hypertension. Thus, from 1051 individuals with normal office blood pressure (BP) belonging to the PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) study population, we selected a group of 675 sustained normotensive individuals in order to provide reliable echocardiographic reference values for defining the criteria of left-ventricular hypertrophy (LVH).
METHODS: : The study group (women 58%, mean age 42 ± 11 years) was identified after excluding individuals with isolated home or ambulatory hypertension, obesity, diabetes, cardiovascular diseases and echocardiographic examinations of insufficient quality to evaluate left-ventricular mass.
RESULTS: : Sex-specific upper limits of normality [mean + 1.96 standard deviation (SD)] for left-ventricular mass, left-ventricular mass indexed to body surface area, heightand height were the following: 213 g, 114 g/m, 51 g/h, 123 g/h in men and 161 g, 99 g/m, 47 g/h, 101 g/h in women. In multivariate analyses, body size measures and ambulatory BP levels were the most important correlates of left-ventricular mass.
CONCLUSIONS: : Our investigation by providing upper reference limits of left-ventricular mass in a southern European population sample, carefully selected after exclusion of a large number of conditions affecting left-ventricular mass, may offer a contribution for revising diagnostic criteria of echocardiographic LVH currently recommended by European hypertension guidelines.
Authors:
Cesare Cuspidi; Rita Facchetti; Carla Sala; Michele Bombelli; Francesca Negri; Stefano Carugo; Roberto Sega; Guido Grassi; Giuseppe Mancia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  30     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  997-1003     Citation Subset:  IM    
Affiliation:
aDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca bIstituto Auxologico Italiano IRCCS cHeart and Lung Department, University of Milano and Fondazione Ospedale Maggiore Policlinico dIstituto IRCCS Multimedica, Sesto san giovanni (Milan), Italy.
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