| Normal skeletal muscle Na(+)-K(+) pump concentration in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 11150968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrinsic changes in skeletal muscle are being increasingly suspected as part of the underlying cause of exercise intolerance in patients with chronic heart failure (CHF). The objective of the present study was to determine whether differences existed between CHF patients and age-matched healthy controls in the concentration of skeletal muscle Na(+)-K(+)-ATPase (adenosine triphosphatase), a cation pump that functions to restore Na(+)-K(+) gradients and protect membrane excitability. Moreover, given the potency for physical activity in altering long-term regulation of the pump, an additional objective was to examine the role of activity level in pump expression in CHF patients. Na(+)-K(+)-ATPase concentration (pmol/g wet wt) determined in the vastus lateralis muscle of 27 CHF males (ejection fraction, 23 +/- 1.6%), using the vanadate facilitated [(3)H] ouabain binding technique, was not different (264 +/- 10) from 10 sedentary controls (268 +/- 19,P > 0.05). Similarly, no differences (P > 0.05) could be found between female patients (228 +/- 16, n = 7) and controls (243 +/- 13, n = 9). Differences between untrained control (294 +/- 20, n = 7), chronically active (251 +/- 20, n = 9), and trained (252 +/- 16, n = 6) CHF groups in Na(+)-K(+) pump expression were also insignificant. This study indicates that long-term regulation of Na(+)-K(+)-ATPase concentration is not altered in moderate CHF patients, regardless of the history of regular activity. However, the positive correlations (P < 0.05) that were observed between peak aerobic power (VO(2) peak) and Na(+)-K(+)-ATPase (r = 0.422) and VO(2) peak and maximal citrate synthase activity (r = 0.404) suggests a role for the skeletal muscle in explaining exercise intolerance in CHF patients. |
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Authors:
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H J Green; B D Duscha; M J Sullivan; S J Keteyian; W E Kraus |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Muscle & nerve Volume: 24 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-18 Completed Date: 2001-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: IM |
Copyright Information:
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Copyright 2001 John Wiley & Sons, Inc. |
Affiliation:
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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada. green@healthy.uwaterloo.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Binding, Competitive
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drug effects Chronic Disease Citrate (si)-Synthase / metabolism Digoxin / administration & dosage Exercise / physiology Exercise Tolerance / drug effects, physiology Female Heart Failure / metabolism* Humans Male Middle Aged Muscle, Skeletal / chemistry, metabolism* Oxidation-Reduction / drug effects Sex Factors Sodium-Potassium-Exchanging ATPase / analysis, metabolism* Stroke Volume |
| Grant Support | |
ID/Acronym/Agency:
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HL 17670/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin; EC 2.3.3.1/Citrate (si)-Synthase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
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