Document Detail

Normal skeletal muscle Na(+)-K(+) pump concentration in patients with chronic heart failure.
MedLine Citation:
PMID:  11150968     Owner:  NLM     Status:  MEDLINE    
Intrinsic changes in skeletal muscle are being increasingly suspected as part of the underlying cause of exercise intolerance in patients with chronic heart failure (CHF). The objective of the present study was to determine whether differences existed between CHF patients and age-matched healthy controls in the concentration of skeletal muscle Na(+)-K(+)-ATPase (adenosine triphosphatase), a cation pump that functions to restore Na(+)-K(+) gradients and protect membrane excitability. Moreover, given the potency for physical activity in altering long-term regulation of the pump, an additional objective was to examine the role of activity level in pump expression in CHF patients. Na(+)-K(+)-ATPase concentration (pmol/g wet wt) determined in the vastus lateralis muscle of 27 CHF males (ejection fraction, 23 +/- 1.6%), using the vanadate facilitated [(3)H] ouabain binding technique, was not different (264 +/- 10) from 10 sedentary controls (268 +/- 19,P > 0.05). Similarly, no differences (P > 0.05) could be found between female patients (228 +/- 16, n = 7) and controls (243 +/- 13, n = 9). Differences between untrained control (294 +/- 20, n = 7), chronically active (251 +/- 20, n = 9), and trained (252 +/- 16, n = 6) CHF groups in Na(+)-K(+) pump expression were also insignificant. This study indicates that long-term regulation of Na(+)-K(+)-ATPase concentration is not altered in moderate CHF patients, regardless of the history of regular activity. However, the positive correlations (P < 0.05) that were observed between peak aerobic power (VO(2) peak) and Na(+)-K(+)-ATPase (r = 0.422) and VO(2) peak and maximal citrate synthase activity (r = 0.404) suggests a role for the skeletal muscle in explaining exercise intolerance in CHF patients.
H J Green; B D Duscha; M J Sullivan; S J Keteyian; W E Kraus
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  24     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-18     Completed Date:  2001-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
Department of Kinesiology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
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MeSH Terms
Binding, Competitive / drug effects
Chronic Disease
Citrate (si)-Synthase / metabolism
Digoxin / administration & dosage
Exercise / physiology
Exercise Tolerance / drug effects,  physiology
Heart Failure / metabolism*
Middle Aged
Muscle, Skeletal / chemistry,  metabolism*
Oxidation-Reduction / drug effects
Sex Factors
Sodium-Potassium-Exchanging ATPase / analysis,  metabolism*
Stroke Volume
Grant Support
Reg. No./Substance:
20830-75-5/Digoxin; EC (si)-Synthase; EC ATPase

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