Document Detail

'Normal' semantic-phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study.
MedLine Citation:
PMID:  19560132     Owner:  NLM     Status:  MEDLINE    
In a meta-analysis of 135 studies involving 6000 patients with Alzheimer's disease (AD) and 6057 healthy controls, we examined the relative degree of semantic and phonemic fluency impairment in AD patients. The effect size for semantic fluency (d=2.10: 95%CI 2.22-1.97) was significantly larger than for both phonemic fluency (d=1.46: 95%CI 1.56-1.36) and picture naming (d=1.54: 95%CI 1.66-1.40). In meta-regression analyses we found that studies with greater proportions of female patients and less severe dementia both led to better phonemic fluency; while perhaps surprisingly, increased patient education led to worse semantic fluency. Critically, in 50 studies measuring both semantic and phonemic fluency, the effect size for the semantic-phonemic discrepancy scores did not differ between AD patients and controls; and was unrelated to any of the moderator variables. The latter findings indicate that the semantic-phonemic fluency discrepancy measure often reported as an important distinguishing characteristic of AD patients may be an exaggerated normal tendency.
Keith R Laws; Amy Duncan; Tim M Gale
Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2009-05-18
Journal Detail:
Title:  Cortex; a journal devoted to the study of the nervous system and behavior     Volume:  46     ISSN:  1973-8102     ISO Abbreviation:  Cortex     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100725     Medline TA:  Cortex     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  595-601     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Srl. All rights reserved.
School of Psychology, University of Hertfordshire, Hatfield, UK.
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MeSH Terms
Age Factors
Alzheimer Disease / complications*
Educational Status
Language Disorders / complications*
Language Tests
Neuropsychological Tests
Regression Analysis
Severity of Illness Index
Sex Characteristics
Speech Disorders / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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