Document Detail

Normal reference values for regional pulmonary peripheral airspace epithelial permeability. Influence of pneumonectomy and the smoking habit.
MedLine Citation:
PMID:  2672207     Owner:  NLM     Status:  MEDLINE    
Peripheral airspace epithelial permeability (PAEP) to diethylentriaminopentacetate (DTPA), an index of pulmonary integrity, was measured in 3 groups of subjects for different purposes: (1) to establish vertical regional reference values; (2) to determine the physiological role of acute doubling of total pulmonary blood flow; (3) to quantify the pulmonary epithelial damage in smokers and the possibility of lung protection by an agent stimulating surfactant production. This study broadens previous knowledge of PAEP. First of all, regional reference values are given for young normal nonsmoking subjects and the existence of a vertical gradient of PAEP is confirmed. Furthermore, this study shows that this gradient is independent of the vertical blood flow gradient, since an acute increase of total blood flow in pneumonectomized patients does not modify the regional distribution of PAEP. Finally, it is confirmed that the cigarette smoker's lung is more permeable than the controls and that probably a drug-stimulating surfactant production gives some protection against damage due to chronic smoking.
T Todisco; M Dottorini; F Rossi; A Baldoncini; R Palumbo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  55     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-29     Completed Date:  1989-09-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  84-93     Citation Subset:  IM    
Cattedra di Fisiopatologia Respiratoria, University of Perugia, Italy.
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MeSH Terms
Epithelium / physiology
Lung / physiology*,  radionuclide imaging
Middle Aged
Mucociliary Clearance
Organometallic Compounds / diagnostic use
Pentetic Acid / diagnostic use
Pulmonary Circulation
Pulmonary Diffusing Capacity
Reference Values
Smoking / physiopathology*
Technetium / diagnostic use
Technetium Tc 99m Pentetate
Reg. No./Substance:
0/Aerosols; 0/Organometallic Compounds; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid; 7440-26-8/Technetium

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