Document Detail

Normal reference range of serum insulin-like growth factor (IGF)-I in healthy Thai adults.
MedLine Citation:
PMID:  19127789     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Serum insulin-like growth factor (IGF)-I level is growth hormone (GH) dependent and reflects GH secretion. Analysis of IGF-I is a component in the diagnosis of GH-related disorders and is going to be of interest in determining the risk of many disorders such as cancer or atherosclerosis. The diagnosis value of IGF-I is dependent on the establishment of an accurate reference ranges, which can be affected by parameters such as age, gender, ethnicity, medications, chronic illness, or assay methodologies. OBJECTIVE: To determine reference ranges of IGF-I for healthy Thai adults. MATERIAL AND METHOD: Eight hundred sixteen healthy Thai adults aged between 21-70 years were recruited in the present study. Serum IGF-I was measured by using immunochemiluminescent (ICMA; Roche, USA). Subjects were recorded by their age and gender groups. Data were presented in mean and +/- 2 standard deviation (SD). Correlation analysis between serum IGF-I and physical parameters including sex, age, weight, height, and body mass index (BMI) was also made. RESULTS: The present study demonstrated normal reference range of serum IGF-I by using mean +/- 2 SD value. The well-known age dependency of serum IGF-I levels was also revealed. Levels decreased with increasing age in both genders. The mean value of serum IGF-I was slightly higher in women at the age of 30-40 years compared with men in the same age group, but not statistically insignificant. In addition, serum IGF-I was found to correlate directly with the height and negatively with BMI. However, age-adjusted IGF-I level did not show correlation with these physical parameters. CONCLUSION: This reference range will be beneficial for using IGF-I assay as a tool in the diagnosis of GH function abnormalities in Thai subjects.
Wanee Plengpanich; Jintara Mangkala; Patinut Buranasukajorn; Kanjana Boonruang; Sarat Sunthornyothin; Sompongse Suwanwalaikorn; Weerapan Khovidhunkit; Vitaya Sridama; Thiti Snabboon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  91     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-01-08     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1681-4     Citation Subset:  IM    
Division of Endocrine and Metabolism, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Patumwan, Bangkok 10330, Thailand.
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MeSH Terms
Age Factors
Biological Assay*
Body Mass Index
Chemiluminescent Measurements
Growth Disorders*
Human Growth Hormone / blood*
Insulin-Like Growth Factor I*
Middle Aged
Reference Values
Sex Factors
Statistics as Topic
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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