Document Detail


Normal reference range of serum insulin-like growth factor (IGF)-I in healthy Thai adults.
MedLine Citation:
PMID:  19127789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Serum insulin-like growth factor (IGF)-I level is growth hormone (GH) dependent and reflects GH secretion. Analysis of IGF-I is a component in the diagnosis of GH-related disorders and is going to be of interest in determining the risk of many disorders such as cancer or atherosclerosis. The diagnosis value of IGF-I is dependent on the establishment of an accurate reference ranges, which can be affected by parameters such as age, gender, ethnicity, medications, chronic illness, or assay methodologies. OBJECTIVE: To determine reference ranges of IGF-I for healthy Thai adults. MATERIAL AND METHOD: Eight hundred sixteen healthy Thai adults aged between 21-70 years were recruited in the present study. Serum IGF-I was measured by using immunochemiluminescent (ICMA; Roche, USA). Subjects were recorded by their age and gender groups. Data were presented in mean and +/- 2 standard deviation (SD). Correlation analysis between serum IGF-I and physical parameters including sex, age, weight, height, and body mass index (BMI) was also made. RESULTS: The present study demonstrated normal reference range of serum IGF-I by using mean +/- 2 SD value. The well-known age dependency of serum IGF-I levels was also revealed. Levels decreased with increasing age in both genders. The mean value of serum IGF-I was slightly higher in women at the age of 30-40 years compared with men in the same age group, but not statistically insignificant. In addition, serum IGF-I was found to correlate directly with the height and negatively with BMI. However, age-adjusted IGF-I level did not show correlation with these physical parameters. CONCLUSION: This reference range will be beneficial for using IGF-I assay as a tool in the diagnosis of GH function abnormalities in Thai subjects.
Authors:
Wanee Plengpanich; Jintara Mangkala; Patinut Buranasukajorn; Kanjana Boonruang; Sarat Sunthornyothin; Sompongse Suwanwalaikorn; Weerapan Khovidhunkit; Vitaya Sridama; Thiti Snabboon
Related Documents :
21966639 - The epidemiology of sarcopenia in community living older adults: what role does lifesty...
21982079 - Hearing impairment in otitis media with effusion: a cross-sectional study based in pokh...
6634709 - Serum estrogen concentrations during postnatal development in male pigs.
20554979 - Identification of late-onset hypogonadism in middle-aged and elderly men.
8300059 - Growth response to growth hormone during the first year as a diagnosis criterion of gro...
23354909 - Primary immunodeficiency diseases in different age groups: a report on 1,008 cases from...
12293139 - Mortality level, trends and differentials in malawi.
9552269 - Stressors and adverse outcomes for female construction workers.
9640119 - Evaluation of the predictive performance of a 'diprifusor' tci system.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  91     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-01-08     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1681-4     Citation Subset:  IM    
Affiliation:
Division of Endocrine and Metabolism, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Patumwan, Bangkok 10330, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Biological Assay*
Body Mass Index
Chemiluminescent Measurements
Female
Growth Disorders*
Human Growth Hormone / blood*
Humans
Immunochemistry
Insulin-Like Growth Factor I*
Male
Middle Aged
Reference Values
Sex Factors
Statistics as Topic
Thailand
Chemical
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hemoglobin E detection using PCR with confronting two-pair primers.
Next Document:  Prevalence of dementia among population age over 45 years in Chiang Mai, Thailand.