Document Detail

Normal psoriatic epidermis expression of hyperproliferation-associated keratins.
MedLine Citation:
PMID:  1724897     Owner:  NLM     Status:  MEDLINE    
Keratin expression in lesional, marginal and uninvolved psoriatic epidermis was analysed by one- and two-dimensional gel electrophoresis and immunoblotting. Keratins K1, K5, K6, K10, K14, and K16 were identified in lesional epidermis. Keratins K6 and K16 were found in all epidermis probes of uninvolved skin, but never occurred in normal epidermis of control skin samples. By means of laser-densitometric evaluation of one-dimensional gels a downregulation of K1 and K10 and an upregulation of K6 and K16 was found in psoriatic epidermis. Unexpectedly, the level of K5 was considerably lower and the level of K14 considerably higher in lesional skin than in normal epidermis. These results demonstrate that not only basal keratinocytes in lesional epidermis but also suprabasal keratinocytes in uninvolved psoriatic epidermis express an altered differentiation pattern. The latter phenomenon could be very important in understanding the development of the so-called "Köbner effect" in psoriatic epidermis.
M Thewes; R Stadler; B Korge; D Mischke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatological research     Volume:  283     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-22     Completed Date:  1992-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Free University of Berlin, Federal Republic of Germany.
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MeSH Terms
Aged, 80 and over
Cell Division
Cells, Cultured
Densitometry / methods
Electrophoresis, Gel, Two-Dimensional
Epidermis / metabolism,  pathology*
Gene Expression / genetics*
Keratins / genetics*,  metabolism
Middle Aged
Psoriasis / genetics,  metabolism,  pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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