Document Detail

Normal pressure perfusion breakthrough after resection of arteriovenous malformation.
MedLine Citation:
PMID:  17894984     Owner:  NLM     Status:  In-Data-Review    
Objectives. The syndrome of normal pressure perfusion breakthrough (NPPB) follows the surgical resection of a small fraction of cerebral arteriovenous malformations (AVM). Although intraoperative hyperemia occurs in NPPB, the relationship and temporal profile of vasomotor paralysis to NPPB are unknown. In the present study, serial transcranial Doppler (TCD) studies (static and stress) were correlated with clinic observations to determine the relationship and temporal profile of vasomotor paralysis to NPPB. Methods. Thirty-five patients underwent complete AVM removal with preservation of the normal arteries and veins. Serial TCD examinations were performed under static and stress conditions (CO(2), Diamox, or blood pressure challenge). Vasomotor paralysis was considered present when CO(2) or Diamox challenge produced less than a 10% change in flow velocity or when flow velocity changed with blood pressure over physiological ranges. Results. Two of 35 patients (6%) developed NPPB immediately after AVM resection. Results of TCD studies were consistent with vasomotor paralysis. NPPB and vasomotor paralysis abated together in both patients on postoperative day 3 to 4. In one patient, NPPB and vasomotor paralysis reoccurred on postoperative day 8 after liberalization of blood pressure control. Conclusions: NPPB occurs in a small fraction of patients after AVM resection. The occurrence of NPPB correlates with vasomotor paralysis, and both are present immediately postoperatively and last several days. Improving vasomotor tone and clinical condition do not imply complete normalization of the cerebral circulation because NPPB and vasomotor paralysis can reoccur after liberalization of blood pressure control.
D Chyatte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  6     ISSN:  1052-3057     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  2007-09-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-6     Citation Subset:  -    
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