Document Detail

'Normal' pregnancy with adverse events on initial tocolytic treatment.
MedLine Citation:
PMID:  17206979     Owner:  NLM     Status:  MEDLINE    
Preterm birth is never low risk and there are advantages gained by prolonging gestation even at relatively advanced stages of pregnancy. This means that high-value treatments should not just be reserved for high-risk pregnancies. Some women treated with tocolytics will experience adverse events, and some adverse events are particularly associated with different classes of tocolytic agents. Cardiovascular adverse events are particularly common with beta-agonists and there have been several maternal deaths from pulmonary oedema as a result of beta-agonist use for tocolysis. Calcium channel blockers are often associated with maternal hypotension, and a number of case studies reporting serious adverse events have been reported. The aim of this case study is to discuss what can be done if a patient experiences adverse events with tocolytics, and suggests approaches to continuing patient management and implications for obstetric practice.
J Dudenhausen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  113 Suppl 3     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-04-24     Revised Date:  2008-09-03    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  116-7     Citation Subset:  AIM; IM    
Obstetric Clinic Charité, Department of Obstetrics, Charité Berlin, Berlin, Germany.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects*
Obstetric Labor, Premature / drug therapy*
Pregnancy Outcome
Pregnancy Trimester, Second
Pulmonary Edema / chemically induced*
Tocolytic Agents / adverse effects*
Vasotocin / analogs & derivatives,  therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Tocolytic Agents; 9034-50-8/Vasotocin; 90779-69-4/atosiban
Erratum In:
BJOG. 2008 Apr;115(5):674-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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