Document Detail


Normal neonatal microbiome variation in relation to environmental factors, infection and allergy.
MedLine Citation:
PMID:  23111681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Bacterial colonization of the infant intestinal tract begins at birth. We are at the forefront of understanding complex relationships between bacteria and multiple parameters of health of the developing infant. Moreover, the establishment of the microbiome in the critical neonatal period is potentially foundational for lifelong health and disease susceptibility. Recent studies utilizing state-of-the-art culture-independent technologies have begun to increase our knowledge about the gut microbiome in infancy, the impact of multiple exposures, and its effects on immune response and clinical outcomes such as allergy and infection.
RECENT FINDINGS: Postnatal exposures play a central role in the complex interactions between the nearly blank canvas of the neonatal intestine, whereas genetic factors do not appear to be a major factor. Infant microbial colonization is affected by delivery mode, dietary exposures, antibiotic exposure, and environmental toxicants. Successive microbiome acquisition in infancy is likely a determinant of early immune programming, subsequent infection, and allergy risk.
SUMMARY: The novel investigation of the neonatal microbiome is beginning to unearth substantial information, with a focus on immune programming that coevolves with the developing microbiome early in life. Several exposures common to neonatal and infant populations could exert pressure on the development of the microbiome and major diseases including allergy and infection in large populations.
Authors:
Juliette C Madan; Shohreh F Farzan; Patricia L Hibberd; Margaret R Karagas
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  24     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  2013-06-04     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Diet
Environmental Exposure
Gastrointestinal Tract / immunology,  microbiology
Humans
Hypersensitivity / immunology*,  microbiology*
Infant, Newborn
Infant, Newborn, Diseases / immunology*,  microbiology*
Infection / immunology*,  microbiology*
Metagenome / immunology*
Reference Values
Grant Support
ID/Acronym/Agency:
2K24AT003683/AT/NCCAM NIH HHS; K24 AT003683/AT/NCCAM NIH HHS; P20 ES018175/ES/NIEHS NIH HHS; P20 ES018175/ES/NIEHS NIH HHS; R25 CA134286/CA/NCI NIH HHS; R25CA134286/CA/NCI NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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