Document Detail

Normal left ventricular diastolic compliance after regression of hypertrophy.
MedLine Citation:
PMID:  7515976     Owner:  NLM     Status:  MEDLINE    
We wished to determine whether (a) left ventricular (LV) diastolic chamber compliance and tissue elastic modulus were decreased with hypertrophy and improved after reversal of hypertension and regression of hypertrophy and whether collagen concentration was a major determinant of LV chamber compliance during hypertrophy or aging. Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), aged 8 months at time of study, were used for the hypertension-regression experiments. The aging study was based on 14- and 24-month-old Fischer-344 rats. LV chamber compliance was measured in isolated perfused hearts arrested in diastole. Length-tension curves (tissue elastic modulus) were obtained from ventricular strips, and hydroxyproline assays were used to estimate LV collagen content. Captopril and hydrochlorothizide were given for an 8-week period to both normotensive and hypertensive rats. Treatment normalized arterial pressure and caused regression of LV hypertrophy in SHR. LV diastolic compliance was less (pressure-volume curve steeper) in SHR than in WKY, but stiffness was similar in the two groups, as indicated by similar slopes when volume was adjusted for heart mass. Treatment significantly decreased ventricular stiffness in both SHR and WKY. Length-tension curves were almost identical in SHR and WKY, but treated SHR demonstrated less tension per given length. These changes occurred although collagen did not decrease in parallel to the decrease in LV mass. Aging was associated with 66 and 60% increases in collagen content and concentration, respectively, but did not alter LV chamber compliance significantly.(ABSTRACT TRUNCATED AT 250 WORDS)
J A Schraeger; C A Canby; B J Rongish; M Kawai; R J Tomanek
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  23     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Department of Anatomy, University of Iowa, Iowa City 52242.
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MeSH Terms
Aging / physiology
Blood Pressure / drug effects,  physiology
Body Weight / physiology
Captopril / pharmacology,  therapeutic use
Cardiomegaly / drug therapy,  physiopathology*
Collagen / metabolism
Diastole / physiology
Elasticity / drug effects
Hydrochlorothiazide / pharmacology
Hydroxyproline / metabolism
Rats, Inbred F344
Rats, Inbred SHR
Rats, Inbred WKY
Vascular Resistance / physiology
Ventricular Function, Left / drug effects,  physiology*
Grant Support
Reg. No./Substance:
51-35-4/Hydroxyproline; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril; 9007-34-5/Collagen

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