| Normal human follicle development: an evaluation of correlations with oestradiol, androstenedione and progesterone levels in individual follicles. | |
| | |
MedLine Citation:
|
PMID: 8849574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The mechanism of dominant follicle selection remains obscure. We have investigated the association between follicle diameter and follicular steroid levels in individual human ovarian follicles throughout the menstrual cycle. DESIGN: Fluid from ovarian follicles (n = 326) was obtained in vivo during surgery from 55 regularly cycling women with proven fertility. Follicles were divided into dominant (diameter >9 mm, n = 45) and non-dominant (diameter < or = 9 mm, n = 281) based on ultrasound measurements. MEASUREMENTS: Fluid was assayed for oestradiol (E2), androstenedione (AD), and progesterone (P). RESULTS: Median P and E2 levels were significantly lower (P < 0.0001) and AD levels significantly higher (P = 0.03) in non-dominant as compared to dominant follicles. In non-dominant follicles AD (r = 0.14, P = 0.02), but not P and E2, levels were correlated to follicular diameter, and significant changes in steroid concentrations across the menstrual cycle were absent. In dominant follicles, diameter was positively correlated with P and E2 (P < 0.001) levels, and inversely correlated with AD concentrations (P = 0.01). CONCLUSIONS: Results indicate that (1) intrafollicular oestradiol concentrations rise only in follicles exceeding 9 mm in diameter and correlate with the diameter of these dominant follicles, suggesting that significant increase in aromatase enzyme activity occurs only in the dominant follicle (2) a cycle-independent accumulation of androstenedione with size occurs in non-dominant follicles, and (3) progesterone production occurs in the largest dominant follicles only, suggesting a limited, if any, role for progesterone during follicle development. |
| | |
Authors:
|
H J van Dessel; I Schipper; T D Pache; H van Geldorp; F H de Jong; B C Fauser |
Related Documents
:
|
22641394 - Leptin and aldosterone in sympathetic activity in resistant hypertension with or withou... 1958534 - The ovarian follicle and fertility. 10865884 - Effect of buffalo follicular fluid treatment on follicle population and ovulation rate ... 3926474 - Interference with the gonadotropin-suppressing actions of estradiol in macaques overrid... 2974844 - Atrial natriuretic peptide in acute mountain sickness. 4042444 - Effects of high caco3 supplements on serum calcium and phosphorus in patients on regula... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical endocrinology Volume: 44 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 191-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Dijkzigt Academic Hospital and Erasmus University Medical School, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Androstenedione / metabolism* Estradiol / metabolism* Female Follicular Fluid / metabolism Humans Menstruation / metabolism Ovarian Follicle / physiology*, ultrasonography Progesterone / metabolism* |
| Chemical | |
Reg. No./Substance:
|
50-28-2/Estradiol; 57-83-0/Progesterone; 63-05-8/Androstenedione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: FSH isoforms: bio and immuno-activities in post-menopausal and normal menstruating women.
Next Document: Relation between serum interleukin-6 and thyroid hormone concentrations in 270 hospital in-patients ...