Document Detail

Normal homeostasis of fibrinolysis in nephrogenic diabetes insipidus in spite of defective V2- receptor-mediated responses of tissue plasminogen activator release.
MedLine Citation:
PMID:  2138555     Owner:  NLM     Status:  MEDLINE    
Three patients with congenital, nephrogenic diabetes insipidus (NDI) from two unrelated families were tested for haemostatic and fibrinolytic responses to DDAVP infusion and venous occlusion. None of the three patients showed a response of factor VIII:C, vWF:Ag or t-PA to DDAVP, a V2-agonist. However, the baseline levels of these factors in the patients' plasma were normal and during venous occlusion a rise in t-PA antigen and t-PA activity was observed in all patients. One patient showed a definite response of the t-PA antigen level to exercise. It is concluded that (extrarenal) V2-receptor-mediated responses are absent in these patients, but that baseline homeostasis and the response to venous occlusion and physical exertion are intact. Presumably, these depend on other mechanisms. This observation denies a central role for vasopressin receptors in the on-demand regulation of clotting and clot dissolving properties of the blood.
E J Brommer; H Brink; F H Derkx; M A Schalekamp; J Stibbe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  20     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-01     Completed Date:  1990-05-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Gaubius Institute TNO, Leiden, The Netherlands.
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MeSH Terms
Deamino Arginine Vasopressin / diagnostic use,  pharmacology
Diabetes Insipidus / complications,  congenital,  physiopathology*
Fibrinolysis / drug effects,  physiology*
Kidney Diseases / complications,  congenital,  physiopathology*
Plasminogen Inactivators / blood
Receptors, Angiotensin / drug effects,  physiology
Receptors, Vasopressin
Tissue Plasminogen Activator / secretion
Reg. No./Substance:
0/Plasminogen Inactivators; 0/Receptors, Angiotensin; 0/Receptors, Vasopressin; 16679-58-6/Deamino Arginine Vasopressin; EC Plasminogen Activator

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