Document Detail

Normal frontal perfusion in patients with frozen gait.
MedLine Citation:
PMID:  9686774     Owner:  NLM     Status:  MEDLINE    
We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of "isolated gait ignition failure" (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe "off" freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.
N Fabre; C Brefel; U Sabatini; P Celsis; J L Montastruc; F Chollet; O Rascol
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  13     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-28     Completed Date:  1998-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
National Institute of Health and Medical Research, INSERM U 455, Department of Neurology, Toulouse, France.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity / physiology
Brain Mapping
Dominance, Cerebral / physiology
Frontal Lobe / blood supply*,  radionuclide imaging
Gait / physiology*
Muscle Rigidity / physiopathology,  radionuclide imaging*
Neurologic Examination
Neurons / physiology
Parkinson Disease / physiopathology,  radionuclide imaging*
Regional Blood Flow / physiology
Supranuclear Palsy, Progressive / physiopathology,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon*
Xenon Radioisotopes / diagnostic use
Reg. No./Substance:
0/Xenon Radioisotopes

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