Document Detail

Normal fibrinolytic responses to 1-desamino-8-D-arginine vasopressin in patients with nephrogenic diabetes insipidus caused by mutations in the aquaporin 2 gene.
MedLine Citation:
PMID:  8730418     Owner:  NLM     Status:  MEDLINE    
Three patients with autosomal-recessive nephrogenic diabetes insipidus (NDI), homozygous for mutations in the aquaporin 2 gene (AQP2), were tested for their fibrinolytic and hemodynamic responses to intravenous administration of 1-desamino-8-D-arginine vasopressin (DDAVP). They all showed an increase of tissue-type plasminogen activator antigen, facial flushing, an increase of heart rate and a decrease of diastolic blood pressure. These results confirm the hypothesis that NDI patients with an AQP2 defect can be discriminated from NDI patients with a vasopressin type 2 receptor defect by their normal extrarenal responses to DDAVP.
A F van Lieburg; V V Knoers; R Mallmann; W Proesmans; L P van den Heuvel; L A Monnens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  72     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1996  
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  544-6     Citation Subset:  IM    
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Aquaporin 2
Aquaporin 6
Deamino Arginine Vasopressin / diagnostic use*
Diabetes Insipidus, Nephrogenic / blood*,  genetics*
Fibrinolysis / drug effects*
Ion Channels / genetics*
Tissue Plasminogen Activator / metabolism
Reg. No./Substance:
0/AQP2 protein, human; 0/Aquaporin 2; 0/Aquaporin 6; 0/Aquaporins; 0/Ion Channels; 16679-58-6/Deamino Arginine Vasopressin; EC Plasminogen Activator

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