| Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: an aid to the diagnosis. | |
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MedLine Citation:
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PMID: 7076117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulfobromophthalein and indocyanine green. Although patients with structural liver disease severe enough to produce hyperbilirubinemia almost invariably have elevated fasting serum levels of cholic acid conjugates, values were normal in each of the Gilbert's syndrome patients, including patients with metabolic abnormalities in sulfobromophthalein and indocyanine green transport. It is concluded that the measurement of fasting serum levels of cholic acid conjugates is a useful adjunct to the diagnosis of Gilbert's syndrome. |
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Authors:
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J M Vierling; P D Berk; A F Hofmann; J F Martin; A W Wolkoff; B F Scharschmidt |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 2 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1982 May-Jun |
Date Detail:
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Created Date: 1982-07-19 Completed Date: 1982-07-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 340-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholic Acids
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blood* Fasting Gilbert Disease / blood*, diagnosis Humans Hyperbilirubinemia, Hereditary / blood* Indocyanine Green / diagnostic use Kinetics Radioimmunoassay Reference Values Sulfobromophthalein / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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AM 16770/AM/NIADDK NIH HHS; AM 21506/AM/NIADDK NIH HHS; AM 264308/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholic Acids; 297-83-6/Sulfobromophthalein; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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