Document Detail


Normal early pregnancy: a transient state of epigenetic change favoring hypomethylation.
MedLine Citation:
PMID:  22647708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to analyze genome-wide differential methylation patterns in maternal leukocyte DNA in early pregnant and non-pregnant states. This is an age and body mass index matched case-control study comparing the methylation patterns of 27,578 cytosine-guanine (CpG) sites in 14,495 genes in maternal leukocyte DNA in early pregnancy (n = 14), in the same women postpartum (n = 14), and in nulligravid women (n = 14) on a BeadChip platform. Transient widespread hypomethylation was found in early pregnancy as compared with the non-pregnant states. Methylation of nine genes was significantly different in early pregnancy compared with both postpartum and nulligravid states (< 10% False Discovery Rate). Early pregnancy may be characterized by widespread hypomethylation compared with non-pregnant states; there is no apparent permanent methylation imprint after a normal term gestation. Nine potential candidate genes were identified as differentially methylated in early pregnancy and may play a role in the maternal adaptation to pregnancy.
Authors:
Wendy M White; Brian C Brost; Zhifu Sun; Carl Rose; Iasmina Craici; Steven J Wagner; Stephen Turner; Vesna D Garovic
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-01
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  7     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-20     Completed Date:  2012-11-12     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Affiliation:
Department of OB/GYN, Division of Maternal Fetal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA. white.wendy@mayo.edu
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE37722
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MeSH Terms
Descriptor/Qualifier:
Adult
DNA Methylation*
Epigenesis, Genetic*
Female
Genetic Loci
Humans
Leukocytes / metabolism
Pregnancy / genetics*
Young Adult
Grant Support
ID/Acronym/Agency:
K08HD051714/HD/NICHD NIH HHS
Comments/Corrections

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