Document Detail


Normal diffusion-weighted MRI during stroke-like deficits.
MedLine Citation:
PMID:  10371524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Diffusion-weighted MRI (DWI) represents a major advance in the early diagnosis of acute ischemic stroke. When abnormal in patients with stroke-like deficit, DWI usually establishes the presence and location of ischemic brain injury. However, this is not always the case. OBJECTIVE: To investigate patients with stroke-like deficits occurring without DWI abnormalities in brain regions clinically suspected to be responsible. METHODS: We identified 27 of 782 consecutive patients scanned when stroke-like neurologic deficits were still present and who had normal DWI in the brain region(s) clinically implicated. Based on all the clinical and radiologic data, we attempted to arrive at a pathophysiologic diagnosis in each. RESULTS: Best final diagnosis was a stroke mimic in 37% and a cerebral ischemic event in 63%. Stroke mimics (10 patients) included migraine, seizures, functional disorder, transient global amnesia, and brain tumor. The remaining patients were considered to have had cerebral ischemic events: lacunar syndrome (7 patients; 3 with infarcts demonstrated subsequently) and hemispheric cortical syndrome (10 patients; 5 with TIA, 2 with prolonged reversible deficits, 3 with infarction on follow-up imaging). In each of the latter three patients, the regions destined to infarct showed decreased perfusion on the initial hemodynamically weighted MRI (HWI). CONCLUSIONS: Normal DWI in patients with stroke-like deficits should stimulate a search for nonischemic cause of symptoms. However, more than one-half of such patients have an ischemic cause as the best clinical diagnosis. Small brainstem lacunar infarctions may escape detection. Concomitant HWI can identify some patients with brain ischemia that is symptomatic but not yet to the stage of causing DWI abnormality.
Authors:
H Ay; F S Buonanno; G Rordorf; P W Schaefer; L H Schwamm; O Wu; R G Gonzalez; K Yamada; G A Sorensen; W J Koroshetz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  52     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-15     Completed Date:  1999-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1784-92     Citation Subset:  AIM; IM    
Affiliation:
Stroke Service of the Neurology Department, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Brain / pathology*
Cerebrovascular Disorders / pathology*
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
5 P50 NS108288-22/NS/NINDS NIH HHS; 5 RO1 NS35284/NS/NINDS NIH HHS; R01-NS28371/NS/NINDS NIH HHS
Comments/Corrections
Comment In:
Neurology. 1999 Jun 10;52(9):1733-6   [PMID:  10371516 ]

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