Document Detail

Normal development of the pulmonary veins in human embryos and formulation of a morphogenetic concept for sinus venosus defects.
MedLine Citation:
PMID:  11165965     Owner:  NLM     Status:  MEDLINE    
A sinus venosus defect is a form of interatrial communication associated with abnormal drainage of the right pulmonary veins. Its morphogenesis still remains unclear. We therefore studied the normal development of pulmonary veins in human embryos in relation to the sinus venosus and the dorsal mesocardium using graphic reconstructions and HNK-1 immunohistochemistry. Twenty embryos, ranging from 4 to 7 weeks' gestation, were examined. At 4 weeks, the orifice of the nonlumenized common pulmonary vein is visible as an endothelial invagination within the sinus venosus segment. Development of the muscular septum primum and the ventral proliferation of extracardiac mesenchyme from the dorsal mesocardium positions the common pulmonary vein (CPV) eventually into the left atrium. The right wall of the CPV contributes to the posterior part of the atrial septum and is continuous with the dorsal sinuatrial fold (the future left venous valve). With the use of HNK-1 antigen expression as a marker for sinus venosus myocardium, this common wall between the right-sided sinus venosus and the CPV is demonstrated, and at 7 weeks the proximal part of the right upper pulmonary vein also becomes part of this common wall. This study demonstrates that the CPV develops within the sinus venosus segment and that later a common myocardial wall is present between the sinus venosus in the right atrium and the CPV. A deficiency of this wall explains the development of sinus venosus defects.
N A Blom; A C Gittenberger-de Groot; T H Jongeneel; M C DeRuiter; R E Poelmann; J Ottenkamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  87     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  AIM; IM    
Department of Pediatric Cardiology, Leiden University Medical Center, The Netherlands.
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MeSH Terms
Antigens, CD57 / analysis
Gestational Age
Heart Atria / embryology
Heart Septal Defects, Atrial / embryology*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Infant, Newborn
Pulmonary Veins / embryology*
Reference Values
Reg. No./Substance:
0/Antigens, CD57

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