| Normal cerebrovascular reactivity in Stroke-like Migraine Attacks after Radiation Therapy syndrome. | |
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MedLine Citation:
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PMID: 20631504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stroke-like Migraine Attacks after Radiation Therapy (SMART) syndrome is a rare complication of cranial irradiation. Radiation is well-known to impair vascular vessel architecture and function. We investigated the hypothesis of radiation-induced cerebral vascular reserve dysfunction as the underlying mechanism of SMART. Interictal cerebrovascular reactivity was investigated using Tc-99m hexamethylpropyleneamine oxime-SPECT and acetazolamide challenge in 3 patients. We found interictal hypoperfusion and normal cerebrovascular reactivity in all patients. Neither ictal restriction of the apparent diffusion coefficient nor MR angiography abnormalities were observed. These findings do not support a vascular mechanism in SMART syndrome. Postradiation neuronal dysfunction may be the underlying mechanism. Further investigations on larger series are needed to confirm this hypothesis. |
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Authors:
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Karim Farid; Wassilios G Meissner; Alexandra Samier-Foubert; Olivier Barret; Patrice Menegon; François Rouanet; Philippe Fernandez; Jean Marc Orgogozo; Michèle Allard; François Tison; Igor Sibon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 35 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 583-5 Citation Subset: IM |
Affiliation:
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CHU de Bordeaux, Service de Médecine Nucléaire, Bordeaux, France. kwfarid@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain / blood supply*, radionuclide imaging Female Humans Male Middle Aged Migraine Disorders / etiology*, physiopathology*, radionuclide imaging Radiotherapy / adverse effects* Stroke* Tomography, Emission-Computed, Single-Photon Young Adult |
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