Document Detail

Normal blood pressure in patients with insulinoma despite hyperinsulinemia and insulin resistance.
MedLine Citation:
PMID:  1457762     Owner:  NLM     Status:  MEDLINE    
This article examines the relationship between blood pressure and serum insulin patients with endogenous hyperinsulinemia due to insulinomas. The hypothesis that hyperinsulinemia is an independent causal factor in the development of essential hypertension in this patient population was investigated. Inappropriately high plasma concentrations of insulin and proinsulin were found in these patients; however, their blood pressure levels did not differ from those of normal control subjects. Moreover, the surgical removal of the insulinomas did not reduce their blood pressure. Therefore, these findings argue against the hypothesis that hyperinsulinemia is an independent causal factor in the development of essential hypertension in humans.
P T Sawicki; T Baba; M Berger; A Starke
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  3     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-01-12     Completed Date:  1993-01-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S64-8     Citation Subset:  IM    
Department of Nutrition and Metabolism (World Health Organization-Collaborating Center for Diabetes), Heinrich-Heine University of Dusseldorf, Germany.
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MeSH Terms
Blood Pressure
Glucose / metabolism
Hyperinsulinism / complications,  physiopathology
Insulin / secretion
Insulin Resistance
Insulinoma / complications,  physiopathology*
Middle Aged
Pancreatic Neoplasms / complications,  physiopathology*
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

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