Document Detail


Normal-appearing white matter in optic neuritis and multiple sclerosis: a comparative proton spectroscopy study.
MedLine Citation:
PMID:  10552024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated neurochemical abnormalities in the normal-appearing white matter (NAWM) on MRI of patients with optic neuritis (ON) and compared them to those of patients with multiple sclerosis (MS). Patients with ON (42) were classified into three groups according to abnormalities on brain MRI. Patients with MS (55) were divided in two groups: relapsing remitting MS (RRMS) and secondary progressive MS (SPMS). All patients underwent MRI of the brain and localised proton magnetic resonance spectroscopy (MRS) of NAWM. The results were compared to those of 15 controls. Patients with MS had significant abnormalities compared with controls and with patients with ON. Patients with RRMS and those with ON had comparable MRS parameters, while patients with SPMS had significant spectroscopic abnormalities in comparison with controls, but also with patients with RRMS. These changes consisted of a decrease in N -acetylaspartate, a neuronal marker, which may reflect axonal dysfunction and/or loss. MRS abnormalities were detected in 14 patients with ON (27 %). The main abnormalities consisted of a decrease in N -acetylaspartate, an increase in choline-containing compounds at long echo times, and the presence of free lipid peaks at short echo times. MRS of the NAWM on MRI may prove useful for detecting neurochemical brain abnormalities in ON not visible on MRI.
Authors:
A Tourbah; J L Stievenart; A Abanou; M T Iba-Zizen; H Hamard; O Lyon-Caen; E A Cabanis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroradiology     Volume:  41     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  738-43     Citation Subset:  IM    
Affiliation:
Service de Neuroradiologie, Centre Hospitalier National d'Ophtalmologie des XV-XX, 28 rue de Charenton, F-75012 Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / pathology*
Female
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multiple Sclerosis / diagnosis*
Optic Neuritis / diagnosis*
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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