Document Detail

Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study.
MedLine Citation:
PMID:  17439881     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the presence and evolution of T(1) relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing-remitting multiple sclerosis (MS).
METHODS: Twenty-three patients with early relapsing-remitting MS and 14 healthy controls were imaged six monthly for up to three years. Mean follow-up was 26 months for MS patients and 24 months for controls. Dual-echo fast-spin echo and gradient-echo proton-density and T(1)-weighted data sets (permitting the calculation of a T(1) map) were acquired in all subjects. GM and NAWM T(1) histograms were produced and a hierarchical regression model was used to investigate changes in T(1) over time.
RESULTS: At baseline, significant patient-control differences were seen, both in NAWM (P <0.001) and in GM (P =0.01). At follow-up, there was no evidence for a serial change in either mean T(1) or peak-location for either NAWM or GM. There was weak evidence for a decline in patient NAWM peak-height and also evidence for a decline in control GM peak-height.
CONCLUSION: There are significant and persistent abnormalities of NAWM and GM T(1) in early relapsing-remitting MS. Further studies should address whether such T(1) measures have a role in prognosis or therapeutic monitoring.
G R Davies; A Hadjiprocopis; D R Altmann; D T Chard; C M Griffin; W Rashid; G J Parker; P S Tofts; R Kapoor; A J Thompson; D H Miller
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-29
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  13     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-18     Completed Date:  2007-06-14     Revised Date:  2011-11-04    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-77     Citation Subset:  IM    
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK.
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MeSH Terms
Brain / pathology*
Disease Progression
Early Diagnosis
Follow-Up Studies
Immunologic Factors / therapeutic use
Interferon-beta / therapeutic use
Longitudinal Studies
Magnetic Resonance Imaging / methods*,  standards
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / drug therapy,  pathology*
Nerve Fibers, Myelinated / pathology*
Regression Analysis
Reproducibility of Results
Grant Support
748//Multiple Sclerosis Society
Reg. No./Substance:
0/Immunologic Factors; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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