Document Detail


Normal antibody-dependent killer cell function in patients with chronic lymphocytic leukemia.
MedLine Citation:
PMID:  300809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unfractionated mononuclear peripheral blood leukocytes (PBL) and nylon wool-nonadherent (B-cell-depleted and T- and null-cell enriched) cells from normal control individuals and untreated patients with chronic lymphocytic leukemia (CLL) were tested for killer cell function in an antibody-dependent cell-mediated cytotoxicity assay. Killer cell activity was present in unfractionated cells from normal individuals and was enriched after removal of adherent cells. Target cell killing by unfractionated mononuclear cells from CLL patients was deficient in 5 of 6 patients tested, but after removal of adherent cells it was approximately equal to that of normal nonadherent cells. Our results indicate that the apparent deficit of killer cells in unfractionated PBL from some CLL patients is due to dilution of killer cells and not to an intrinsic defect in the function of these cells, the presence of suppressor cells in the adherent population, or suppression of killer cell function by serum factors.
Authors:
J B Smith; R P Knowlton; L S Koons
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  58     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1497-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies*
Cell Adhesion
Cytotoxicity Tests, Immunologic
Female
Humans
Immunity, Cellular
Leukemia, Lymphoid / immunology*
Lymphocytes / immunology*
Male
Receptors, Antigen, B-Cell
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Receptors, Antigen, B-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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