Document Detail

Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes.
MedLine Citation:
PMID:  23039889     Owner:  NLM     Status:  MEDLINE    
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4(+) CD294(+) Th2 cells, and associated negatively with CD3(+) T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8(+) T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
A S Mansfield; W K Nevala; R S Dronca; A A Leontovich; L Shuster; S N Markovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-93     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
Departments of Oncology Medicine, Division of Hematology Immunology Biomedical Statistics and Informatics Women's Health Clinic, Division of General Internal Medicine, Mayo Clinic Rochester, MN 55905, USA.
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MeSH Terms
Aged, 80 and over
Aging / immunology*,  metabolism
Antigens, CD3 / immunology,  metabolism
Antigens, CD4 / immunology,  metabolism
B-Lymphocyte Subsets / immunology,  metabolism
CD40 Ligand / immunology,  metabolism*
Chemokine CCL2 / immunology,  metabolism*
Chemokine CCL5 / immunology,  metabolism*
Cytokines / immunology,  metabolism
Melanoma / immunology,  metabolism
Middle Aged
Platelet-Derived Growth Factor / immunology,  metabolism*
Receptors, Immunologic / immunology,  metabolism
Receptors, Prostaglandin / immunology,  metabolism
Sex Factors
T-Lymphocyte Subsets / immunology,  metabolism
Th2 Cells / immunology*,  metabolism
Young Adult
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, CD4; 0/CCL2 protein, human; 0/CCL5 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/Cytokines; 0/Platelet-Derived Growth Factor; 0/Receptors, Immunologic; 0/Receptors, Prostaglandin; 0/platelet-derived growth factor A; 0/prostaglandin D2 receptor; 147205-72-9/CD40 Ligand

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