Document Detail

Normal adult values, diurnal variation, and repeatability of nasal nitric oxide measurement.
MedLine Citation:
PMID:  10582119     Owner:  NLM     Status:  MEDLINE    
Reports of elevated nasal nitric oxide (NO) levels in allergic rhinitis suggest that nasal NO levels could be a valuable marker of upper airway inflammation, provided that the reproducibility of nasal NO measurement is acceptable. The aims of this study were to evaluate the precision with which nasal NO levels can be measured at single point in time, and to quantify within-day and between-day variation. Nasal NO was measured using a modified chemiluminescence analyzer. Population data were normally distributed, as judged by testing for skewness and kurtosis. NO levels were not related to age or gender, and there was no evidence of diurnal variation. Sampling rates of 250 mL/minute and 500 mL/minute at a single point in time had acceptable reproducibility (coefficients of variation 10.2% and 6.6%, respectively). However, within-day variation (coefficient of variation 13.4%) and between-day variation (coefficient of variation 11.8%), at a sampling rate of 500 L/minute, were substantially higher. These findings highlight the importance of taking measurement variation into account, in the interpretation of NO levels, in clinical research and, potentially, in routine practice. In individual patients, an alteration of 20-25% in NO levels is required, to ensure that change is genuine and not ascribable to the noise of measurement.
J Bartley; W Fergusson; A Moody; A U Wells; J Kolbe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of rhinology     Volume:  13     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-12-23     Completed Date:  1999-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Department of Otolaryngology, Green Lane Hospital, Auckland, New Zealand.
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MeSH Terms
Analysis of Variance
Chemiluminescent Measurements
Circadian Rhythm / physiology*
Middle Aged
Nitric Oxide / analysis*
Nose / physiology*
Reference Values
Reproducibility of Results
Specimen Handling / methods
Time Factors
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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