Document Detail


Normal adult height among girls treated for central precocious puberty with gonadotropin-releasing hormone analog therapy.
MedLine Citation:
PMID:  19554804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate adult height (AH) among girls with central precocious puberty (CPP) treated with gonadotropin releasing hormone analog (GnRHa) and to assess the impact of posttreatment growth on AH. STUDY DESIGN: Medical records of girls with CPP were reviewed. RESULTS: Twenty-six girls aged 7.2 +/- 2.0 years were identified. There was a significant difference between AH and predicted adult height (PAH) at the initiation of therapy (p = 0.005). Using univariate analysis, the only factor associated with AH was total growth after discontinuation of therapy. Growth after discontinuation of therapy was variable and often greater than expected. Both age and skeletal age at the end of therapy had strong linear relationships with growth after therapy explaining 60% of this growth. CONCLUSION: This report confirms that AH is normal among females with CPP treated in a timely fashion with GnRHa. The lack of predictability of growth after discontinuation of therapy suggests that the decision to stop treatment should be individualized.
Authors:
Zeina M Nabhan; Lori K St-Dennis Feezle; Allen R Kunselman; Nancy B Johnson; Peter A Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
Affiliation:
Section of Pediatric Endocrinology/Diabetology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indiana 46202, USA. znabhan@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Determination by Skeleton
Child
Child Development
Child, Preschool
Female
Follow-Up Studies
Gonadotropin-Releasing Hormone / analogs & derivatives*,  therapeutic use*
Growth Disorders
Humans
Infant
Puberty, Precocious / drug therapy*
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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