Document Detail


Normal and abnormal fetal growth.
MedLine Citation:
PMID:  16612110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fetal origins of adult disease hypothesis suggests that poor intrauterine growth is associated with an increased risk of cardiovascular disease. The hypothesis goes on to implicate different growth 'phenotypes', particularly disproportionate growth, in the determination of the type of cardiovascular disease that develops. Analysis of the antenatal growth of a low-risk pregnancy population does not identify such growth phenotypes within the general population. Rather, intrauterine growth is characterized by poor predictability of subsequent size, suggesting that centile crossing is a common feature of intrauterine growth. Furthermore, there is a sexually dimorphic pattern to this growth that needs to be considered in further work to test the fetal origins hypothesis.
Authors:
S M Bryan; P C Hindmarsh
Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-10
Journal Detail:
Title:  Hormone research     Volume:  65 Suppl 3     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-13     Completed Date:  2006-06-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
London Centre of Paediatric Endocrinology and Metabolism, Institute of Child Health, University College London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biometry
Birth Weight / physiology*
Female
Fetal Development / genetics,  physiology*
Fetal Growth Retardation / diagnosis*
Humans
Insulin / physiology
Male
Maternal Age
Maternal Nutritional Physiological Phenomena
Parity / physiology
Placenta / physiology
Pregnancy
Sex Characteristics
Smoking / adverse effects
Somatomedins / physiology
Chemical
Reg. No./Substance:
0/Somatomedins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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