| Normal Uptake of 68Ga-DOTA-TOC by the Pancreas Uncinate Process Mimicking Malignancy at Somatostatin Receptor PET. | |
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MedLine Citation:
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PMID: 22391705 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : To characterize a commonly occurring increased uptake by the uncinate process of the pancreas at PET/CT using Ga-DOTA-d-Phe-Tyr-octreotide (Ga-DOTA-TOC). This tracer has replaced In pentetreotide (OctreoScan®) for somatostatin receptor scintigraphy at our laboratory. METHODS: : Fifty of our first 74 PET/CT examinations with Ga-DOTA-TOC could be evaluated in retrospect. None of these patients had surgery or showed any pathology in the pancreas head at the concomitant CT. RESULTS: : Thirty-five of the 50 examinations (70%) showed an uptake by the uncinate process sufficiently intense to be interpreted as pathologic and simulating a tumor. Mean SUVmax was 9.2. Mean SUVmean using an isoactivity cut-off of >75% and >50% was 7.8 and 6.0, respectively. Volume calculations of the uncinate process activity using these definitions gave 0.9 mL and 4.2 mL, respectively. CONCLUSION: : There is a frequent physiological uptake of Ga-DOTA-TOC by the pancreas uncinate process. This may be caused by an accumulation of pancreatic polypeptide-containing cells expressing somatostatin receptors. If there is a normal finding at concomitant diagnostic CT, this uptake should be regarded as physiological. |
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Authors:
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Hans Jacobsson; Patricia Larsson; Cathrine Jonsson; Emma Jussing; Per Grybäck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 37 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 362-5 Citation Subset: IM |
Affiliation:
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From the Departments of *Radiology, †Nuclear Medicine, and ‡Neuroradiology, Karolinska University Hospital Solna, Stockholm, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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