| Normal T lymphocyte function in patients with end-stage renal disease hemodialyzed with 'high-flux' polysulfone membranes. | |
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MedLine Citation:
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PMID: 2240054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T lymphocyte function was analyzed in patients hemodialyzed with 'high-flux' polysulfone membranes, which have been reported to improve the patients' overall clinical condition and well-being. For comparison purposes, patients treated by the use of 'low-flux' cuprophane membranes were also studied. Peripheral blood white cell counts, numbers of lymphocytes as well as the numbers of T cells and their CD4 and CD8 subsets were within normal range in both patient groups. The absolute number of B cells was slightly decreased in cuprophane-membrane- but not polysulfone-membrane-treated patients. The proliferative response of T lymphocytes after stimulation with optimal concentration of phytohemagglutinin (PHA) was normal in patients treated with 'high-flux' membrane dialysis but significantly reduced in those treated with cuprophane membranes. The generation of interleukin-2 (IL-2) receptor on T lymphocytes after PHA stimulation was normal in the polysulfone-membrane-treated group and slightly impaired in the cuprophane-membrane-dialyzed patients. Production of both IL-2 and interleukin-1, as well as the natural killer cell activity, in patients treated by 'high-flux' membrane dialysis were also comparable to controls. The levels of serum beta 2-microglobulin were significantly elevated in patients-maintained on 'high-flux' dialysis membranes but did not reach the levels seen in patients dialyzed by cuprophane membranes. The beta 2-microglobulin at levels seen in patients on cuprophane dialysis had no effects on activation and proliferation of control lymphocytes in vitro. These results suggest that impaired functional responses of T lymphocytes seen in end-stage disease patients on prolonged hemodialysis with cuprophane membranes are not seen in similar patients hemodialyzed with polysulfone membranes. |
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Authors:
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D Degiannis; M Czarnecki; D Donati; L Homer; R P Eisinger; K Raska; J Raskova |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of nephrology Volume: 10 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-12-20 Completed Date: 1990-12-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 276-82 Citation Subset: IM |
Affiliation:
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Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials* Cellulose / analogs & derivatives Female Humans Kidney Failure, Chronic / therapy* Leukocyte Count Male Membranes, Artificial* Middle Aged Polymers* Receptors, Interleukin-2 / analysis Renal Dialysis* Sulfones* T-Lymphocyte Subsets / physiology T-Lymphocytes / physiology* beta 2-Microglobulin / analysis |
| Grant Support | |
ID/Acronym/Agency:
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AI-25914/AI/NIAID NIH HHS; CA-21196/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Membranes, Artificial; 0/Polymers; 0/Receptors, Interleukin-2; 0/Sulfones; 0/beta 2-Microglobulin; 25135-51-7/polysulfone P 1700; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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