Document Detail

Normal T lymphocyte function in patients with end-stage renal disease hemodialyzed with 'high-flux' polysulfone membranes.
MedLine Citation:
PMID:  2240054     Owner:  NLM     Status:  MEDLINE    
T lymphocyte function was analyzed in patients hemodialyzed with 'high-flux' polysulfone membranes, which have been reported to improve the patients' overall clinical condition and well-being. For comparison purposes, patients treated by the use of 'low-flux' cuprophane membranes were also studied. Peripheral blood white cell counts, numbers of lymphocytes as well as the numbers of T cells and their CD4 and CD8 subsets were within normal range in both patient groups. The absolute number of B cells was slightly decreased in cuprophane-membrane- but not polysulfone-membrane-treated patients. The proliferative response of T lymphocytes after stimulation with optimal concentration of phytohemagglutinin (PHA) was normal in patients treated with 'high-flux' membrane dialysis but significantly reduced in those treated with cuprophane membranes. The generation of interleukin-2 (IL-2) receptor on T lymphocytes after PHA stimulation was normal in the polysulfone-membrane-treated group and slightly impaired in the cuprophane-membrane-dialyzed patients. Production of both IL-2 and interleukin-1, as well as the natural killer cell activity, in patients treated by 'high-flux' membrane dialysis were also comparable to controls. The levels of serum beta 2-microglobulin were significantly elevated in patients-maintained on 'high-flux' dialysis membranes but did not reach the levels seen in patients dialyzed by cuprophane membranes. The beta 2-microglobulin at levels seen in patients on cuprophane dialysis had no effects on activation and proliferation of control lymphocytes in vitro. These results suggest that impaired functional responses of T lymphocytes seen in end-stage disease patients on prolonged hemodialysis with cuprophane membranes are not seen in similar patients hemodialyzed with polysulfone membranes.
D Degiannis; M Czarnecki; D Donati; L Homer; R P Eisinger; K Raska; J Raskova
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of nephrology     Volume:  10     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-20     Completed Date:  1990-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  276-82     Citation Subset:  IM    
Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway.
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MeSH Terms
Biocompatible Materials*
Cellulose / analogs & derivatives
Kidney Failure, Chronic / therapy*
Leukocyte Count
Membranes, Artificial*
Middle Aged
Receptors, Interleukin-2 / analysis
Renal Dialysis*
T-Lymphocyte Subsets / physiology
T-Lymphocytes / physiology*
beta 2-Microglobulin / analysis
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 0/Membranes, Artificial; 0/Polymers; 0/Receptors, Interleukin-2; 0/Sulfones; 0/beta 2-Microglobulin; 25135-51-7/polysulfone P 1700; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose

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