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Normal Quantity and Distribution of Mast Cells and Eosinophils in the Pediatric Colon.
MedLine Citation:
PMID:  21341989     Owner:  NLM     Status:  Publisher    
Abstract The normal number and distribution of mast cells (MCs) and eosinophils in colonic mucosa is largely unknown. Accordingly, we examined colonic biopsies obtained during endoscopic examination of pediatric patients. The study included 41 patients (21 males and 20 females). The mean age was 11.72 years (range 3.3-19.7 years). Patients were followed up for a mean time of 23.4 months (range 12-50 months). Our results showed a gradual decrease in the number of eosinophils in the lamina propria from the cecum to the descending colon (14.2 ± 6.1 and 10.7 ± 5.6 eosinophils//hpf, respectively) with another peak in the rectosigmoid (12.4 ± 6.1 eosinophils/hpf). Eosinophils within the surface and crypt epithelium were more commonly encountered in the cecum and the rectosigmoid. Eosinophils clusters were rare but were more frequently found in the cecum and rectosigmoid. The highest number of MCs was observed in the descending colon and the lowest in the rectosigmoid (17.56 ± 7.28 and 14.5 ± 6.35 MCs/hpf, respectively). No MCs were identified within the surface epithelium. Very rare MCs were observed within the crypt epithelium with the highest number observed in the cecum (0.34 ± 0.53 MCs/hpf) and the lowest number observed in the descending colon (0.02 ± 0.16 MCs/hpf). More MCs were present in the cecum and descending colon of females vs. males (P value 0.02 and 0.04, respectively). Our results establish baseline gastrointestinal eosinophils and MCs counts in various parts of the pediatric colon.
Ali Saad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-22
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Arkansas Children's Hospital.
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