Document Detail


Normal development of the lung and premature birth.
MedLine Citation:
PMID:  20692626     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The following review focuses on the normal development of the lung from conception to birth. The defined periods of lung development-Embryonic, Pseudoglandular, Canalicular, Saccular and Alveolar-will be explored in detail in relation to gestational age. Cellular differentiation, formation of the conducting airways and respiratory zone and development of the alveoli will be reviewed. Pulmonary vascular development will also be examined within these periods to relate the formation of the blood-air barrier to the lungs for their essential function of gas exchange after birth. The development of the surfactant and cortisol systems will also be discussed as these need to be mature before the lungs are able to take on their role of respiration following birth. It is clear that premature birth interrupts normal lung development so the effect of preterm birth on lung development will be examined and the respiratory consequences of very preterm birth will be briefly explored.
Authors:
Lucia J Smith; Karen O McKay; Peter P van Asperen; Hiran Selvadurai; Dominic A Fitzgerald
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Publication Detail:
Type:  Journal Article     Date:  2010-01-25
Journal Detail:
Title:  Paediatric respiratory reviews     Volume:  11     ISSN:  1526-0550     ISO Abbreviation:  Paediatr Respir Rev     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898941     Medline TA:  Paediatr Respir Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-42     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Respiratory Medicine, The Children's Hospital at Westmead, Locked Bag 4001 Westmead NSW Australia 2145.
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