| Normal central zone of the prostate and central zone involvement by prostate cancer: clinical and MR imaging implications. | |
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MedLine Citation:
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PMID: 22357889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the anatomic features of the central zone of the prostate on T2-weighted and diffusion-weighted (DW) magnetic resonance (MR) images and evaluate the diagnostic performance of MR imaging in detection of central zone involvement by prostate cancer. MATERIALS AND METHODS: The institutional review board waived informed consent and approved this retrospective, HIPAA-compliant study of 211 patients who underwent T2-weighted and DW MR imaging of the prostate before radical prostatectomy. Whole-mount step-section pathologic findings were the reference standard. Two radiologists independently recorded the visibility, MR signal intensity, size, and symmetry of the central zone and scored the likelihood of central zone involvement by cancer on T2-weighted MR images and on T2-weighted MR images plus apparent diffusion coefficient (ADC) maps generated from the DW MR images. Descriptive summary statistics were calculated for central zone imaging features. Sensitivity, specificity, and area under the curve were used to evaluate reader performance in detecting central zone involvement. RESULTS: For readers 1 and 2, the central zone was visible, at least partially, in 177 (84%) and 170 (81%) of 211 patients, respectively. The most common imaging appearance of the central zone was symmetric, homogeneous low signal intensity. Cancers involving the central zone had higher prostate-specific antigen values, Gleason scores, and rates of extracapsular extension and seminal vesicle invasion compared with cancers not involving the central zone (P < .05). Area under the curve, sensitivity, and specificity in detecting central zone involvement were 0.70, 0.30, and 0.96 for reader 1 and 0.65, 0.35, and 0.93 for reader 2, and these values did not differ significantly between T2-weighted imaging and T2-weighted imaging plus ADC maps. CONCLUSION: The central zone was visualized in most patients. Cancers involving the central zone were associated with more aggressive disease than those without central zone involvement. |
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Authors:
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Hebert Alberto Vargas; Oguz Akin; Tobias Franiel; Debra A Goldman; Kazuma Udo; Karim A Touijer; Victor E Reuter; Hedvig Hricak |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Radiology Volume: 262 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-23 Completed Date: 2012-04-27 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 894-902 Citation Subset: AIM; IM |
Copyright Information:
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© RSNA, 2012. |
Affiliation:
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Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C-278, New York, NY 10065, USA. vargasah@mskcc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Area Under Curve Humans Magnetic Resonance Imaging / methods* Male Middle Aged Prostate / anatomy & histology* Prostatectomy Prostatic Neoplasms / pathology*, surgery Retrospective Studies Sensitivity and Specificity Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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CA076423/CA/NCI NIH HHS |
| Comments/Corrections | |
Erratum In:
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Radiology. 2012 Aug;264(2):617 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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