Document Detail


Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency.
MedLine Citation:
PMID:  20881272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected.
METHODS: This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.
RESULTS: Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.
CONCLUSION: These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.
Authors:
V Worthington; J Killestein; M J Eikelenboom; C E Teunissen; F Barkhof; C H Polman; B M J Uitdehaag; A Petzold
Publication Detail:
Type:  Journal Article     Date:  2010-09-29
Journal Detail:
Title:  Neurology     Volume:  75     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2010-11-29     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1617-22     Citation Subset:  AIM; IM    
Affiliation:
Department of Neuroimmunology, UCL Institute of Neurology, University College London, Queen Square, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Cross-Sectional Studies
Disability Evaluation
Enzyme-Linked Immunosorbent Assay / methods
Female
Ferritins / cerebrospinal fluid*
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multiple Sclerosis / cerebrospinal fluid*
Statistics as Topic
Venous Insufficiency / diagnosis,  etiology*
Chemical
Reg. No./Substance:
9007-73-2/Ferritins
Comments/Corrections
Comment In:
Neurology. 2011 Jun 14;76(24):2130-1; author reply 2130-1   [PMID:  21670445 ]
Neurology. 2011 Jun 14;76(24):2131; author reply 2131-2
Neurology. 2011 Jun 14;76(24):2130; author reply 2130-1
J Neurol. 2010 Dec;257(12):2114-6   [PMID:  21104093 ]
Neurology. 2010 Nov 2;75(18):1581-2   [PMID:  20881276 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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