| Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency. | |
| | |
MedLine Citation:
|
PMID: 20881272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected. METHODS: This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders. RESULTS: Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period. CONCLUSION: These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS. |
| | |
Authors:
|
V Worthington; J Killestein; M J Eikelenboom; C E Teunissen; F Barkhof; C H Polman; B M J Uitdehaag; A Petzold |
Publication Detail:
|
Type: Journal Article Date: 2010-09-29 |
Journal Detail:
|
Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-02 Completed Date: 2010-11-29 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 1617-22 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neuroimmunology, UCL Institute of Neurology, University College London, Queen Square, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cohort Studies Cross-Sectional Studies Disability Evaluation Enzyme-Linked Immunosorbent Assay / methods Female Ferritins / cerebrospinal fluid* Humans Magnetic Resonance Imaging / methods Male Middle Aged Multiple Sclerosis / cerebrospinal fluid* Statistics as Topic Venous Insufficiency / diagnosis, etiology* |
| Chemical | |
Reg. No./Substance:
|
9007-73-2/Ferritins |
| Comments/Corrections | |
Comment In:
|
Neurology. 2011 Jun 14;76(24):2130-1; author reply 2130-1
[PMID:
21670445
]
Neurology. 2011 Jun 14;76(24):2131; author reply 2131-2 Neurology. 2011 Jun 14;76(24):2130; author reply 2130-1 J Neurol. 2010 Dec;257(12):2114-6 [PMID: 21104093 ] Neurology. 2010 Nov 2;75(18):1581-2 [PMID: 20881276 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in fiber tract integrity and visual fields after anterior temporal lobectomy.
Next Document: Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis.