Document Detail


Norflurazon--an inhibitor of essential fatty acid desaturation in isolated liver cells.
MedLine Citation:
PMID:  4058269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Norflurazon is a herbicide known to inhibit carotene biosynthesis and linolenic acid biosynthesis in plants. In the present work, the effect of norflurazon on the metabolism of studied in isolated rat liver cells and in rat liver microsomes, incubated with [1-14C] labeled linolenic acid (18:3, n-3), dihomogammalinolenic acid (20:3, n-6) and eicosapentaenoic acid (20:5, n-3). Norflurazon (0.1 mM, 1.0 mM) was found to inhibit essential fatty acid desaturation. The delta 6 desaturation is inhibited more efficiently than the delta 5 and delta 4 desaturation. The chain elongation of essential C18 fatty acids to their C20 and C22 homologs was not inhibited by norflurazon.
Authors:
T A Hagve; B O Christophersen; P Böger
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Lipids     Volume:  20     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-16     Completed Date:  1985-12-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  719-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Fatty Acid Desaturases / metabolism*
Fatty Acids, Essential / metabolism*
Herbicides / pharmacology*
Kinetics
Linoleic Acid
Linoleic Acids / metabolism
Liver / drug effects,  metabolism*
Male
Microsomes, Liver / drug effects,  metabolism
Pyridazines / pharmacology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids, Essential; 0/Herbicides; 0/Linoleic Acids; 0/Pyridazines; 2197-37-7/Linoleic Acid; 27314-13-2/norflurazone; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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