Document Detail

Norflurazon--an inhibitor of essential fatty acid desaturation in isolated liver cells.
MedLine Citation:
PMID:  4058269     Owner:  NLM     Status:  MEDLINE    
Norflurazon is a herbicide known to inhibit carotene biosynthesis and linolenic acid biosynthesis in plants. In the present work, the effect of norflurazon on the metabolism of studied in isolated rat liver cells and in rat liver microsomes, incubated with [1-14C] labeled linolenic acid (18:3, n-3), dihomogammalinolenic acid (20:3, n-6) and eicosapentaenoic acid (20:5, n-3). Norflurazon (0.1 mM, 1.0 mM) was found to inhibit essential fatty acid desaturation. The delta 6 desaturation is inhibited more efficiently than the delta 5 and delta 4 desaturation. The chain elongation of essential C18 fatty acids to their C20 and C22 homologs was not inhibited by norflurazon.
T A Hagve; B O Christophersen; P Böger
Related Documents :
7929259 - Delta 9 acyl-lipid desaturases of cyanobacteria. molecular cloning and substrate specif...
12945699 - Modelling the hydrolysis of succinimide: formation of aspartate and reversible isomeriz...
4062949 - Ethanol sensitivity and fatty acid composition of chick liver mitochondrial and microso...
15820139 - Stearoyl-coa desaturase expression and fatty acid composition in milkfish (chanos chano...
2247449 - Biosynthesis of vitamin b12: isolation of precorrin-6x, a metal-free precursor of the c...
2114179 - Fatty acid metabolism in human lymphocytes. ii. activation of fatty acid desaturase-elo...
8111249 - Incorporation of radioactive phosphate from adenosine triphosphate into phosphatidylino...
931799 - Studies on pleuromutilin and some of its derivatives.
5075269 - Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pi...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Lipids     Volume:  20     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-16     Completed Date:  1985-12-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  719-22     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbon Radioisotopes
Fatty Acid Desaturases / metabolism*
Fatty Acids, Essential / metabolism*
Herbicides / pharmacology*
Linoleic Acid
Linoleic Acids / metabolism
Liver / drug effects,  metabolism*
Microsomes, Liver / drug effects,  metabolism
Pyridazines / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids, Essential; 0/Herbicides; 0/Linoleic Acids; 0/Pyridazines; 2197-37-7/Linoleic Acid; 27314-13-2/norflurazone; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  GSH-dependent inhibition of lipid peroxidation: properties of a potent cytosolic system which protec...
Next Document:  The liver in biliary obstruction due to chronic pancreatitis.