| Norfloxacin-poly(L-lysine citramide imide) conjugates and structure-dependence of the drug release. | |
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MedLine Citation:
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PMID: 15512781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Norfloxacin (Nflx), an antibiotic which is active against some intracellular bacteria, was coupled to a polymeric carrier, namely poly(L-lysine citramide) via a lysine or an ethylcarbamate spacer to obtain a macromolecular prodrug. The carrier, which derived from the two metabolites citric acid and L-lysine, is known to be biocompatible and slowly degradable under slight acidic conditions. Conjugates were characterised by UV, 1H and 13C NMR and SEC. The presence of Norfloxacin and the lysine type spacer caused chain aggregation, due to a probable physical cure. The release of Norfloxacin from these prodrugs and from a prodrug where Norfloxacin is bound to the carrier backbone without spacer arm was investigated comparatively in vitro. Conjugation via a carbamate-type linkage appeared as a method to achieve the release of Norfloxacin from a PLCA-type conjugate at neutral. |
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Authors:
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Stéphanie Gac-Breton; Jean Coudane; Mahfoud Boustta; Michel Vert |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of drug targeting Volume: 12 ISSN: 1061-186X ISO Abbreviation: J Drug Target Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-10-29 Completed Date: 2004-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: England |
Other Details:
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Languages: eng Pagination: 297-307 Citation Subset: IM |
Affiliation:
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CRBA-UMR CNRS 5473, Faculty of Pharmacy, Montpellier I University, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Carriers Hydrogen-Ion Concentration Norfloxacin / administration & dosage*, chemistry Nylons* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Nylons; 0/poly(lysine citramide imide); 70458-96-7/Norfloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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