| Norfloxacin therapy for hepatopulmonary syndrome: a pilot randomized controlled trial. | |
| | |
MedLine Citation:
|
PMID: 20816858 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: The hepatopulmonary syndrome occurs in up to one-third of patients with cirrhosis. Animal models of this disease suggest that endotoxemia might cause nitric oxide-mediated vascular dilatation that can be inhibited by the antibiotic norfloxacin. We sought to test this hypothesis in humans. METHODS: We conducted a pilot randomized, controlled crossover trial of norfloxacin 400 mg twice daily for 4 weeks with a 4-week washout period to assess the feasibility of a larger trial. The primary clinical end point was change in alveolar-arterial oxygen gradient (AaDO₂). RESULTS: Recruitment was challenging, and change in AaDO₂ was highly variable. We recruited 9 adults (1 woman; age, 60 ± 9 years; AaDO₂, 50 ± 22 mm Hg). AaDO₂ decreased by 0.8 ± 4.8 and 3.4 ± 12.4 mm Hg while on norfloxacin and placebo, respectively (P = .59). CONCLUSIONS: Recruitment difficulties and variability of the primary outcome measure suggest the need for a multicenter clinical research network for future therapeutic trials in this disease. There was no major effect of norfloxacin on gas exchange in patients with hepatopulmonary syndrome. |
| | |
Authors:
|
Samir Gupta; Marie E Faughnan; Les Lilly; Stuart Hutchison; Robert Fowler; Ahmed M Bayoumi |
Related Documents
:
|
22468258 - Clinical manifestations and role of proton pump inhibitors in the management of laryngo... 22507058 - Randomized clinical trials: is periodontal research good for patients? 22555988 - A randomized control trial to evaluate the beyondblue depression training program: does... 22426398 - How does the brain deal with cumulative stress? a review with focus on developmental st... 2645988 - Control of severe pain with sustained-release morphine tablets v. oral morphine solution. 17178958 - Povidone-iodine vs sodium hypochlorite enema for mechanical preparation before elective... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-09 |
Journal Detail:
|
Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 8 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
|
Languages: eng Pagination: 1095-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Medicine, University of Toronto, Ontario, Canada. guptas@smh.toronto.on.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantifying the interaction structure and the topological importance of species in food webs: a sign...
Next Document: Skin discoloration from compulsive bathing in a patient with hyperemesis syndrome.