| Norethisterone concentration in breast milk and infant and maternal plasma during ethynodiol diacetate administration. | |
MedLine Citation:
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PMID: 4042659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twelve women with established lactation of 4-8 weeks duration were given a low-dose progestogen-only contraceptive, ethynodiol diacetate 0.5 mg (Femulen) daily. On the seventh and eight day of the study, prior to the mother's taking the pill, a blood sample was taken from her and from the infant. Further blood samples were collected from the mother 4 and 12 hours later. Breast milk samples were collected at every feed on day 7 and day 8. Ethynodiol diacetate is rapidly metabolised in humans, changing into the metabolite norethisterone which is found in both blood and milk. Hence, norethisterone concentrations were estimated. On day 7 and day 8, four hours after ingestion of the pill, the median norethisterone maternal plasma concentration was 1.60 ng/ml and it fell to a median level of 0.30 ng/ml prior to the next dose of the pill. At this time the median infant concentration was 0.10 ng/ml but the maximum observed level was 0.50 ng/ml. In the breast milk the norethisterone concentration appears to peak at around 4-8 hours following the ingestion of the pill. The maximum observed concentration in breast milk was 0.84 ng/ml. The amount of norethisterone ingested by the infant averaged 0.02% (6.65 micrograms) of the dose of ethynodiol diacetate ingested by the mother. The maximum observed on any one day was 0.07% (27.52 micrograms). The above results indicate that the amount of progestogen ingested by the infant from its mother's milk is small and is unlikely to pose a risk to the infant. |
Authors:
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I D Cooke; D J Back; N E Shroff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contraception Volume: 31 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-11-18 Completed Date: 1985-11-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 611-21 Citation Subset: IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biotransformation Contraceptives, Oral, Synthetic / administration & dosage*, adverse effects, metabolism Ethynodiol Diacetate / administration & dosage*, adverse effects, metabolism Female Humans Infant, Newborn Kinetics Milk, Human / metabolism* Norethindrone / blood, metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Synthetic; 297-76-7/Ethynodiol Diacetate; 68-22-4/Norethindrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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