Document Detail

Norepinephrine stimulates amylase release from pancreatic acini.
MedLine Citation:
PMID:  6190041     Owner:  NLM     Status:  MEDLINE    
alpha-Adrenergic blockade decreases food-stimulated amylase secretion in dogs, suggesting that physiologic sympathetic nerve discharge of norepinephrine enhances pancreatic enzyme secretion. Previous studies have not separated direct effects of adrenergic agonists on pancreatic exocrine cells from effects on blood flow. An in vitro preparation of dispersed acini from guinea pig pancreas was modified and amylase release in response to common pancreatic stimulants was measured. It was demonstrated that physiologic concentrations of norepinephrine enhance amylase release from dispersed pancreatic acini evoked by supramaximal concentrations of cholecystokinin. These observations suggest that the sympathetic nervous system plays a role in modulating pancreatic enzyme secretion independent of effects on blood flow.
R J Joehl; R C Rose; D L Nahrwold
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  34     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-9     Citation Subset:  IM    
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MeSH Terms
Amylases / secretion*
Atropine / pharmacology
Carbachol / pharmacology
Cholecystokinin / pharmacology
Guinea Pigs
Norepinephrine / pharmacology*
Pancreas / enzymology,  secretion*
Peptide Fragments / pharmacology
Secretin / pharmacology
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 1393-25-5/Secretin; 25126-32-3/Sincalide; 51-41-2/Norepinephrine; 51-55-8/Atropine; 51-83-2/Carbachol; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases

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