| Norepinephrine stimulates amylase release from pancreatic acini. | |
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MedLine Citation:
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PMID: 6190041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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alpha-Adrenergic blockade decreases food-stimulated amylase secretion in dogs, suggesting that physiologic sympathetic nerve discharge of norepinephrine enhances pancreatic enzyme secretion. Previous studies have not separated direct effects of adrenergic agonists on pancreatic exocrine cells from effects on blood flow. An in vitro preparation of dispersed acini from guinea pig pancreas was modified and amylase release in response to common pancreatic stimulants was measured. It was demonstrated that physiologic concentrations of norepinephrine enhance amylase release from dispersed pancreatic acini evoked by supramaximal concentrations of cholecystokinin. These observations suggest that the sympathetic nervous system plays a role in modulating pancreatic enzyme secretion independent of effects on blood flow. |
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Authors:
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R J Joehl; R C Rose; D L Nahrwold |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of surgical research Volume: 34 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1983 Jun |
Date Detail:
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Created Date: 1983-07-15 Completed Date: 1983-07-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 543-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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secretion* Animals Atropine / pharmacology Carbachol / pharmacology Cholecystokinin / pharmacology Guinea Pigs Norepinephrine / pharmacology* Pancreas / enzymology, secretion* Peptide Fragments / pharmacology Secretin / pharmacology Sincalide |
| Grant Support | |
ID/Acronym/Agency:
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AM22188/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 1393-25-5/Secretin; 25126-32-3/Sincalide; 51-41-2/Norepinephrine; 51-55-8/Atropine; 51-83-2/Carbachol; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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