Document Detail

Norepinephrine levels in discrete brain nuclei in borderline hypertensive rats exposed to compound stressors.
MedLine Citation:
PMID:  8879671     Owner:  NLM     Status:  MEDLINE    
The borderline hypertensive rat (BHR) appears to be an appropriate model for investigating the role of the environment in producing hypertension. Previous studies have demonstrated that the BHR shows chronic blood pressure elevations to both stress and high salt intake. Other studies suggest that interactions between the brain and kidney play an important role in initiating this hypertension. The central noradrenergic system has been implicated in these effects, especially in the hypothalamus. Because exercise has been found to attenuate stress-induced hypertension in the BHR, the current study sought to examine the impact of stressors paired with exercise (salt intake or stress) with those combining stress and high salt. Male BHR were exposed to either control, salt plus stress, salt plus exercise, or stress plus exercise conditions for either 2 or 6 months, beginning at 2 months of age. Following sacrifice, brain nuclei in the brain stem and hypothalamus were removed using the Palkovits micropunch technique. Punches were analyzed for NE content via liquid chromatography with electrochemical detection. Compared with the control condition, chronic salt plus stress led to reductions in NE content, especially in the hypothalamus. Compared with salt plus stress, the exercise conditions were associated with elevated NE levels, especially in the early phases of exposure to the treatment. The possible role of exercise training in preventing a central nervous system trigger from inducing hypertension in the BHR is discussed.
J E Lawler; G Zheng; S Li; C H Wang; I P Edgemon
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  41     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-03     Completed Date:  1997-02-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Department of Psychology, University of Tennessee, Knoxville 37996-0900, USA.
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MeSH Terms
Brain Stem / cytology,  metabolism*
Chromatography, High Pressure Liquid
Hypertension / metabolism*,  pathology
Hypothalamus / cytology,  metabolism*
Norepinephrine / metabolism*
Physical Exertion / physiology
Rats, Inbred SHR
Rats, Inbred WKY
Stress, Psychological / metabolism*,  pathology
Time Factors
Grant Support
Reg. No./Substance:

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