Document Detail


Norepinephrine kinetics in older women: relationship to physical activity and blood pressure.
MedLine Citation:
PMID:  9762528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sympathetic nervous system participates in the regulation of carbohydrate, lipid, and energy metabolism, and has been implicated in the pathogenesis of hypertension and obesity. Increased sympathetic nervous system activity with age may alter disease risk and contribute to the development of certain chronic diseases. Thus, we examined possible determinants of sympathetic nervous system activity in older normotensive women from infusions of tritiated norepinephrine (NE) to estimate rates of norepinephrine appearance and clearance. A secondary aim was to examine the association between norepinephrine kinetics and mean supine arterial blood pressure. Twenty-two older women (65.7 +/- 5.7 years) were characterized for resting NE kinetics, body composition, body fat distribution, peak aerobic capacity, leisure time physical activity energy expenditure (LTA), dietary carbohydrates, and daily energy intake. Analysis of univariate correlations revealed that only the LTA was significantly correlated with plasma NE appearance (r = 0.54, p < 0.01). Stepwise regression analysis identified LTA as the only significant predictor of plasma NE appearance rate with a total R2 = 0.29. The waist-to-hip ratio was selected as the only significant predictor of mean arterial blood pressure with an R2 = 0.30. When forced into the model, plasma NE appearance explained only 1% of the unique variance in mean arterial blood pressure. In summary, we found that: (1) higher levels of physical activity are related to higher plasma NE appearance in older women; (2) greater central body fatness is an independent predictor of mean arterial blood pressure; and (3) plasma NE appearance rate is a minor contributor to variation in mean arterial blood pressure in older, normotensive women.
Authors:
R V Dvorak; E T Poehlman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental gerontology     Volume:  33     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  507-16     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Vermont, Burlington 05405, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue
Aged
Aging / metabolism*
Blood Pressure / physiology
Body Constitution / physiology
Cohort Studies
Data Interpretation, Statistical
Diastole
Energy Intake / physiology
Energy Metabolism / physiology
Exercise / physiology
Exercise Test
Female
Humans
Middle Aged
Norepinephrine / blood,  pharmacokinetics*
Systole
Vasoconstrictor Agents / blood,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
KO4-AGO0564/AG/NIA NIH HHS; R01-AG07857/AG/NIA NIH HHS; RR-109/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine

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