| Norepinephrine kinetics in older women: relationship to physical activity and blood pressure. | |
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MedLine Citation:
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PMID: 9762528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sympathetic nervous system participates in the regulation of carbohydrate, lipid, and energy metabolism, and has been implicated in the pathogenesis of hypertension and obesity. Increased sympathetic nervous system activity with age may alter disease risk and contribute to the development of certain chronic diseases. Thus, we examined possible determinants of sympathetic nervous system activity in older normotensive women from infusions of tritiated norepinephrine (NE) to estimate rates of norepinephrine appearance and clearance. A secondary aim was to examine the association between norepinephrine kinetics and mean supine arterial blood pressure. Twenty-two older women (65.7 +/- 5.7 years) were characterized for resting NE kinetics, body composition, body fat distribution, peak aerobic capacity, leisure time physical activity energy expenditure (LTA), dietary carbohydrates, and daily energy intake. Analysis of univariate correlations revealed that only the LTA was significantly correlated with plasma NE appearance (r = 0.54, p < 0.01). Stepwise regression analysis identified LTA as the only significant predictor of plasma NE appearance rate with a total R2 = 0.29. The waist-to-hip ratio was selected as the only significant predictor of mean arterial blood pressure with an R2 = 0.30. When forced into the model, plasma NE appearance explained only 1% of the unique variance in mean arterial blood pressure. In summary, we found that: (1) higher levels of physical activity are related to higher plasma NE appearance in older women; (2) greater central body fatness is an independent predictor of mean arterial blood pressure; and (3) plasma NE appearance rate is a minor contributor to variation in mean arterial blood pressure in older, normotensive women. |
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Authors:
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R V Dvorak; E T Poehlman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental gerontology Volume: 33 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-12-03 Completed Date: 1998-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 507-16 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Vermont, Burlington 05405, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Aged Aging / metabolism* Blood Pressure / physiology Body Constitution / physiology Cohort Studies Data Interpretation, Statistical Diastole Energy Intake / physiology Energy Metabolism / physiology Exercise / physiology Exercise Test Female Humans Middle Aged Norepinephrine / blood, pharmacokinetics* Systole Vasoconstrictor Agents / blood, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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KO4-AGO0564/AG/NIA NIH HHS; R01-AG07857/AG/NIA NIH HHS; RR-109/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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