Document Detail


Norepinephrine-induced beta 1-adrenergic peripheral vasodilation in conscious dogs.
MedLine Citation:
PMID:  2861749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Norepinephrine (NE) elicits alpha-adrenergic vasoconstriction and beta 1-adrenergic increases in heart rate and myocardial contractility. To determine whether NE can also elicit peripheral beta 1-adrenergic vasodilation, conscious dogs were studied after recovery from instrumentation for the measurement of cardiac output, arterial pressure, and left ventricular (LV) pressure and calculations of LV dP/dt and total peripheral resistance (TPR). NE, after pretreatment with hexamethonium and phentolamine, reduced mean arterial pressure 40 +/- 5% from 117 +/- 9 mmHg and TPR 60 +/- 5% from 0.058 +/- 0.007 mmHg X ml-1 X min and increased cardiac output 55 +/- 11% from 2,159 +/- 188 ml/min. beta 1-Adrenergic blockade with atenolol reversed the vasodilation induced by NE completely, while at this time isoproterenol was still able to reduce peripheral resistance further, by 67 +/- 7%, indicating that beta 2-adrenergic receptors were not blocked. Administration of phentolamine to intact dogs caused a fall in mean arterial pressure (23 +/- 5%) and TPR (34 +/- 5.4%) and an endogenous increase in plasma NE (2,987 +/- 905 pg/ml) and epinephrine (584 +/- 92 pg/ml). These increases in cardiac output and decreases in TPR were also reversed by atenolol (0.5 mg/kg). Moreover, this dose of atenolol blocked the increases in iliac blood flow induced by local injection of NE in the limb. Thus, in the presence of alpha-adrenergic receptor blockade, either administration of NE or release of endogenous NE elicits potent peripheral vasodilation, which appears to involve a beta 1-adrenergic receptor mechanism.
Authors:
S F Vatner; D R Knight; T H Hintze
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-13     Completed Date:  1985-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H49-56     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Animals
Atenolol / pharmacology
Blood Pressure / drug effects
Cardiac Output / drug effects
Dogs
Epinephrine / pharmacology
Ethanolamines / pharmacology
Female
Hexamethonium
Hexamethonium Compounds / pharmacology
Isoproterenol / pharmacology
Male
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology*
Phentolamine / pharmacology
Receptors, Adrenergic, alpha / drug effects
Receptors, Adrenergic, beta / drug effects*,  physiology
Vascular Resistance / drug effects
Vasodilation / drug effects*
Grant Support
ID/Acronym/Agency:
HL-05936/HL/NHLBI NIH HHS; HL-06440/HL/NHLBI NIH HHS; HL-33107/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Ethanolamines; 0/Hexamethonium Compounds; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 29122-68-7/Atenolol; 38677-81-5/pirbuterol; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60-26-4/Hexamethonium; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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