Document Detail

Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  7188643     Owner:  NLM     Status:  MEDLINE    
Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.
M G Ziegler; B R Brooks; C R Lake; J H Wood; S J Enna
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  30     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  AIM; IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / blood,  cerebrospinal fluid*
Muscular Diseases / blood,  cerebrospinal fluid
Nervous System Diseases / blood,  cerebrospinal fluid
Norepinephrine / blood,  cerebrospinal fluid*
gamma-Aminobutyric Acid / blood,  cerebrospinal fluid*
Reg. No./Substance:
51-41-2/Norepinephrine; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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