Document Detail


Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  7188643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.
Authors:
M G Ziegler; B R Brooks; C R Lake; J H Wood; S J Enna
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  30     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amyotrophic Lateral Sclerosis / blood,  cerebrospinal fluid*
Female
Humans
Male
Muscular Diseases / blood,  cerebrospinal fluid
Nervous System Diseases / blood,  cerebrospinal fluid
Norepinephrine / blood,  cerebrospinal fluid*
gamma-Aminobutyric Acid / blood,  cerebrospinal fluid*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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