| Norepinephrine depresses the immunity and disease-resistance ability via α1- and β1-adrenergic receptors of Macrobrachium rosenbergii. | |
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MedLine Citation:
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PMID: 21295067 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, we determined the effects of norepinephrine (NE) on immunity and the pathway of its function in the freshwater giant prawn, Macrobrachium rosenbergii. The total hemocyte count (THC), differential hemocyte count (DHC), phenoloxidase activity, respiratory bursts, superoxide dismutase (SOD) activity, phagocytic activity, and clearance efficiency in response to the pathogen, Lactococcus garvieae, were measured when the freshwater giant prawn, M. rosenbergii (16.2±2.1g) was individually injected with saline or NE at 0.5, 5.0, and 50.0 pmol prawn(-1). Results showed that semi-granular cells, respiratory bursts and phagocytic activity at 2h, PO activity and clearance efficiency from 2 to 4h, THC at 8h, and SOD activity from 4 to 8h significantly decreased, but hyaline cells at 2h, and respiratory bursts at 8h had significantly increased after injection of NE at 50.0 pmol prawn(-1). In prawns that had received 5.0 pmol NE prawn(-1), the PO activity had decreased at 2h, SOD activity at 8h, and the clearance efficiency at 2h. PO activity had decreased at 2h after prawns had received 0.5 pmol NE prawn(-1). All of the immune parameters had returned to control values by 16h after receiving NE. However, no significant differences were observed in the granular cells during the experimental period. An injection of NE also significantly increased the mortality of prawns challenged with L. garvieae, which appeared to be dose dependent. In another experiment, NE co-injected with prazosin, metoprolol, or propranolol significantly decreased the mortality of challenged prawns, especially when co-injected with prazosin and metoprolol. These results suggest that stress-inducing NE suppresses the immune system, which in turn promotes the susceptibility of M. rosenbergii to L. garvieae via both α1- and β1-adrenergic receptors. |
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Authors:
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Chin-Chyuan Chang; Ming-Di Hung; Winton Cheng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: - ISSN: 1879-0089 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. |
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