| Norephedrine (phenylpropanolamine) stimulates oxygen consumption and lactate production in the perfused rat hindlimb. | |
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MedLine Citation:
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PMID: 2010256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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d,l-Norephedrine (phenylpropanolamine) which is both a demethylated analogue and a metabolite of d,l-ephedrine, is a reputed anorectic agent. In the present study the proposed most active isomer of this mixture, l-norephedrine has been assessed as a peripherally acting thermogenic agent in the isolated perfused rat hindlimb. l-Norephedrine produced a dose-dependent increase in oxygen uptake and perfusion pressure and increased lactate production. Whereas propranolol potentiated the increase in oxygen uptake and perfusion pressure produced by l-norephedrine, prazosin significantly and nitroprusside totally inhibited both of these changes. Nitroprusside also completely inhibited the increase in lactate production. We conclude that norephedrine has a hitherto unrecognized peripheral thermogenic activity in the perfused rat hindlimb resulting from its interaction with alpha 1 adrenergic receptors that control vasoconstriction in this tissue. |
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Authors:
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M Hettiarachchi; E Q Colquhoun; J M Ye; S Rattigan; M G Clark |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of obesity Volume: 15 ISSN: 0307-0565 ISO Abbreviation: Int J Obes Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-05-09 Completed Date: 1991-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703240 Medline TA: Int J Obes Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 37-43 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Tasmania, Hobart, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hindlimb Lactates / biosynthesis* Male Muscles / drug effects*, metabolism Oxygen Consumption / drug effects* Perfusion Phenylpropanolamine / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 14838-15-4/Phenylpropanolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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