| Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs. | |
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MedLine Citation:
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PMID: 16551579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO(-)), singlet oxygen ((1)O(2)), hydroxyl radical (OH(v)), hydrogen peroxide (H(2)O(2)), superoxide anion and hypochlorous acid (HOCl) scavenging capacity of NDGA. It was found that NDGA scavenges: (a) ONOO(-) (IC(50) = 4 +/- 0.94 microM) as efficiently as uric acid; (b) (1)O(2) (IC(50) = 151 +/- 20 microM) more efficiently than dimethyl thiourea, lipoic acid, N-acetyl-cysteine and glutathione; (c) OH(v) (IC(50) = 0.15 +/- 0.02 microM) more efficiently than dimethyl thiourea, uric acid, trolox, dimethyl sulfoxide and mannitol, (d) (IC(50) = 15 +/- 1 microM) more efficiently than N-acetyl-cysteine, glutathione, tempol and deferoxamine and (e) HOCl (IC(50) = 622 +/- 42 microM) as efficiently as lipoic acid and N-acetyl-cysteine. NDGA was unable to scavenge H(2)O(2). In an in vivo study in rats, NDGA was able to prevent ozone-induced tyrosine nitration in lungs. It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo. |
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Authors:
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Esaú Floriano-Sánchez; Cleva Villanueva; Omar Noel Medina-Campos; Diana Rocha; Dolores Javier Sánchez-González; Noemí Cárdenas-Rodríguez; José Pedraza-Chaverrí |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 40 ISSN: 1071-5762 ISO Abbreviation: Free Radic. Res. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-03-22 Completed Date: 2006-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 523-33 Citation Subset: IM |
Affiliation:
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Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón S/N, Col. Casco de Santo Tomás, México, México. floriano_esa@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / chemistry, pharmacology Dose-Response Relationship, Drug Free Radical Scavengers / chemistry, pharmacology* Hydroxyl Radical / metabolism Hypochlorous Acid / metabolism Immunohistochemistry Lung / drug effects*, metabolism Male Nordihydroguaiaretic Acid / chemistry, pharmacology* Ozone / pharmacology* Peroxynitrous Acid / metabolism Rats Rats, Wistar Reactive Oxygen Species / metabolism* Singlet Oxygen / metabolism Superoxides / metabolism Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 10028-15-6/Ozone; 11062-77-4/Superoxides; 14691-52-2/Peroxynitrous Acid; 17778-80-2/Singlet Oxygen; 3352-57-6/Hydroxyl Radical; 500-38-9/Nordihydroguaiaretic Acid; 55520-40-6/Tyrosine; 7790-92-3/Hypochlorous Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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