Document Detail

Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.
MedLine Citation:
PMID:  16551579     Owner:  NLM     Status:  MEDLINE    
The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO(-)), singlet oxygen ((1)O(2)), hydroxyl radical (OH(v)), hydrogen peroxide (H(2)O(2)), superoxide anion and hypochlorous acid (HOCl) scavenging capacity of NDGA. It was found that NDGA scavenges: (a) ONOO(-) (IC(50) = 4 +/- 0.94 microM) as efficiently as uric acid; (b) (1)O(2) (IC(50) = 151 +/- 20 microM) more efficiently than dimethyl thiourea, lipoic acid, N-acetyl-cysteine and glutathione; (c) OH(v) (IC(50) = 0.15 +/- 0.02 microM) more efficiently than dimethyl thiourea, uric acid, trolox, dimethyl sulfoxide and mannitol, (d) (IC(50) = 15 +/- 1 microM) more efficiently than N-acetyl-cysteine, glutathione, tempol and deferoxamine and (e) HOCl (IC(50) = 622 +/- 42 microM) as efficiently as lipoic acid and N-acetyl-cysteine. NDGA was unable to scavenge H(2)O(2). In an in vivo study in rats, NDGA was able to prevent ozone-induced tyrosine nitration in lungs. It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo.
Esaú Floriano-Sánchez; Cleva Villanueva; Omar Noel Medina-Campos; Diana Rocha; Dolores Javier Sánchez-González; Noemí Cárdenas-Rodríguez; José Pedraza-Chaverrí
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  40     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  523-33     Citation Subset:  IM    
Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón S/N, Col. Casco de Santo Tomás, México, México.
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MeSH Terms
Antioxidants / chemistry,  pharmacology
Dose-Response Relationship, Drug
Free Radical Scavengers / chemistry,  pharmacology*
Hydroxyl Radical / metabolism
Hypochlorous Acid / metabolism
Lung / drug effects*,  metabolism
Nordihydroguaiaretic Acid / chemistry,  pharmacology*
Ozone / pharmacology*
Peroxynitrous Acid / metabolism
Rats, Wistar
Reactive Oxygen Species / metabolism*
Singlet Oxygen / metabolism
Superoxides / metabolism
Tyrosine / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 10028-15-6/Ozone; 11062-77-4/Superoxides; 14691-52-2/Peroxynitrous Acid; 17778-80-2/Singlet Oxygen; 3352-57-6/Hydroxyl Radical; 500-38-9/Nordihydroguaiaretic Acid; 55520-40-6/Tyrosine; 7790-92-3/Hypochlorous Acid

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