Document Detail

Noradrenergic neurotransmission within the bed nucleus of the stria terminalis modulates the retention of immobility in the rat forced swimming test.
MedLine Citation:
PMID:  23625378     Owner:  NLM     Status:  In-Data-Review    
The bed nucleus of the stria terminalis (BNST) is a limbic structure that has a direct influence on the autonomic, neuroendocrine, and behavioral responses to stress. It was recently reported that reversible inactivation of synaptic transmission within this structure causes antidepressant-like effects, indicating that activation of the BNST during stressful situations would facilitate the development of behavioral changes related to the neurobiology of depression. Moreover, noradrenergic neurotransmission is abundant in the BNST and has an important role in the regulation of emotional processes related to the stress response. Thus, this study aimed to test the hypothesis that activation of adrenoceptors within the BNST facilitates the development of behavioral consequences of stress. To investigate this hypothesis, male Wistar rats were stressed (forced swimming, 15 min) and 24 h later received intra-BNST injections of vehicle, WB4101, RX821002, CGP20712, or ICI118,551, which are selective α1, α2, β1, and β2 adrenoceptor antagonists, respectively, 10 min before a 5-min forced swimming test. It was observed that administration of WB4101 (10 and 15 nmol), CGP20712 (5 and 10 nmol), or ICI118,551 (5 nmol) into the BNST reduced the immobility time of rats subjected to forced swimming test, indicating an antidepressant-like effect. These findings suggest that activation of α1, β1, and β2 adrenoceptors in the BNST could be involved in the development of the behavioral consequences of stress.
Michelly M Nagai; Felipe V Gomes; Carlos C Crestani; Leonardo B M Resstel; Sâmia R L Joca
Related Documents :
2528758 - Intermittent high altitude--induced changes in energy metabolism in the rat myocardium ...
23639878 - Repeated restraint stress impairs auditory attention and gabaergic synaptic efficacy in...
1357978 - Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation...
25301688 - Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced park...
8285268 - Sex difference in the antidiuretic activity of vasopressin in the rat.
2391408 - Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. part 2. the ef...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  24     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
aDepartment of Physics and Chemistry, School of Pharmaceutical Sciences bDepartment of Pharmacology, School of Medicine, University of São Paulo, Ribeirão Preto cLaboratory of Pharmacology, Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, São Paulo State University, UNESP, Araraquara, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thoracoscopic resection of a giant mediastinal parathyroid cyst.
Next Document:  Evaluation of functional relationship between mouse hippocampal cholinergic and nitrergic systems in...