Document Detail


Noradrenergic hyperactivity in primary hypertension; central and peripheral markers of both behavioral pathogenesis and efficacy of sympatholytic and relaxation therapy.
MedLine Citation:
PMID:  3072125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of clonidine or relaxation therapy were determined in two separate groups of patients with primary hypertension. Ten patients were treated with clonidine monotherapy for 3 months. There were concurrent reductions of blood pressure, plasma and CSF norepinephrine, all p less than 0.01. The changes of blood pressure and norepinephrine were correlated, p less than 0.05 and 0.01, respectively. Thirty patients received hygienic instructions, and 17 of them had relaxation training in addition. Relaxation lowered blood pressures, p less than 0.01, the reduction of blood pressure was related to baseline plasma norepinephrine, p less than 0.05, and greater in patients with "raised" plasma norepinephrine, p less than 0.02. Plasma norepinephrine was lowered after hygienic therapy, p less than 0.05, the change was not significant after relaxation training. Arterial pressure elevation appears to be related to raised plasma norepinephrine. This noradrenergic hyperactivity is a marker for blood pressure responsiveness to sympatholytic therapy with clonidine or relaxation techniques.
Authors:
D D Lee; V DeQuattro; G C Davison; S Kimura; R Barndt; P Sullivan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-34     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Southern California, Los Angeles.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Clonidine / administration & dosage,  therapeutic use*
Combined Modality Therapy
Female
Humans
Hypertension / physiopathology,  therapy*
Male
Middle Aged
Norepinephrine / metabolism*
Relaxation Therapy*
Grant Support
ID/Acronym/Agency:
2R01 HL31090-04A1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
4205-90-7/Clonidine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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