Document Detail

Noradrenergic hyperactivity in primary hypertension; central and peripheral markers of both behavioral pathogenesis and efficacy of sympatholytic and relaxation therapy.
MedLine Citation:
PMID:  3072125     Owner:  NLM     Status:  MEDLINE    
The effects of clonidine or relaxation therapy were determined in two separate groups of patients with primary hypertension. Ten patients were treated with clonidine monotherapy for 3 months. There were concurrent reductions of blood pressure, plasma and CSF norepinephrine, all p less than 0.01. The changes of blood pressure and norepinephrine were correlated, p less than 0.05 and 0.01, respectively. Thirty patients received hygienic instructions, and 17 of them had relaxation training in addition. Relaxation lowered blood pressures, p less than 0.01, the reduction of blood pressure was related to baseline plasma norepinephrine, p less than 0.05, and greater in patients with "raised" plasma norepinephrine, p less than 0.02. Plasma norepinephrine was lowered after hygienic therapy, p less than 0.05, the change was not significant after relaxation training. Arterial pressure elevation appears to be related to raised plasma norepinephrine. This noradrenergic hyperactivity is a marker for blood pressure responsiveness to sympatholytic therapy with clonidine or relaxation techniques.
D D Lee; V DeQuattro; G C Davison; S Kimura; R Barndt; P Sullivan
Related Documents :
24231965 - Comparison of approaches to quantify arterial damping capacity from pressurization test...
1809555 - The effect of exogenous dopamine on canine trachea.
665535 - Abrupt cessation of clonidine administration: a prospective study.
2565395 - Time-dependent enhancement of xylazine-induced, alpha-2 adrenoceptor-mediated vasoconst...
2959425 - Comparative hemodynamic dose-response effects of five slow calcium channel-blocking age...
1622255 - High-pressure, high-temperature bioreactor for comparing effects of hyperbaric and hydr...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-34     Citation Subset:  IM    
Department of Medicine, University of Southern California, Los Angeles.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Clonidine / administration & dosage,  therapeutic use*
Combined Modality Therapy
Hypertension / physiopathology,  therapy*
Middle Aged
Norepinephrine / metabolism*
Relaxation Therapy*
Grant Support
2R01 HL31090-04A1/HL/NHLBI NIH HHS
Reg. No./Substance:
4205-90-7/Clonidine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New insights into the influence of pulsatile pressure on the arterial baroreceptor reflex.
Next Document:  Relationship between pain sensitivity, cardiovascular reactivity to cold pressor test and indexes of...