Document Detail


Noradrenergic function and the mechanism of action of antianxiety treatment. I. The effect of long-term alprazolam treatment.
MedLine Citation:
PMID:  2859008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is preclinical and clinical evidence suggesting that one neural mechanism responsible for antipanic efficacy is a reduction in brain noradrenergic function. Alprazolam, a triazolobenzodiazepine, has been demonstrated to have antipanic properties; however, to our knowledge, its effects on noradrenergic function have not been established. To assess whether alprazolam alters noradrenergic function, the effects of alprazolam on baseline plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and yohimbine-induced increases in plasma MHPG level, anxiety-nervousness, blood pressure, and somatic symptoms were studied in 14 patients with agoraphobia and panic disorder. Long-term alprazolam treatment significantly reduced plasma MHPG baseline and blunted the yohimbine-induced increases in plasma MHPG, anxiety-nervousness, and sitting systolic blood pressure. These observations suggest that the antipanic mechanism of action of alprazolam may be due in part to an interaction between benzodiazepine-sensitive and noradrenergic neural systems.
Authors:
D S Charney; G R Heninger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  42     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-05-21     Completed Date:  1985-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  458-67     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Agoraphobia / drug therapy,  metabolism
Alprazolam
Anti-Anxiety Agents / pharmacology*,  therapeutic use
Anxiety Disorders / drug therapy*,  metabolism
Benzodiazepines / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Brain / drug effects*,  metabolism
Female
Humans
Male
Methoxyhydroxyphenylglycol / blood
Middle Aged
Norepinephrine / metabolism*
Panic / drug effects
Receptors, Adrenergic, alpha / drug effects
Receptors, GABA-A / drug effects,  metabolism
Sympathetic Nervous System / drug effects*,  metabolism
Synaptic Transmission / drug effects
Time Factors
Yohimbine / pharmacology
Grant Support
ID/Acronym/Agency:
MH-25642/MH/NIMH NIH HHS; MH-36229/MH/NIMH NIH HHS; MH-38007/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Receptors, Adrenergic, alpha; 0/Receptors, GABA-A; 12794-10-4/Benzodiazepines; 146-48-5/Yohimbine; 28981-97-7/Alprazolam; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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