| Noradrenergic function in schizophrenia. | |
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MedLine Citation:
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PMID: 3662745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Yohimbine, an alpha 2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 16 healthy subjects and 18 drug-free schizophrenic patients with (n = 10) and without (n = 8) tardive dyskinesia (TD). Outcome measures of this double-blind, placebo-controlled study included changes in behavior, plasma 3-methoxy-4-hydroxy-phenylglycol (MHPG) level, blood pressure, and heart rate. A subgroup of six patients experienced a notable dysphoric arousal reaction that occurred 60 to 90 minutes following administration of 20 mg of yohimbine, this reaction was not observed in healthy subjects. The schizophrenic group as a whole (not the subgroup) showed a statistical trend toward a greater yohimbine-induced increase in plasma MHPG level and systolic sitting blood pressure. The patients with TD did not differ from those without TD or from healthy controls in their response to yohimbine. These results do not support the hypothesis that noradrenergic dysfunction plays a strong central role in the pathogenesis of schizophrenia or TD. However, further studies of noradrenergic dysfunction in sub-groups of patients with schizophrenia are indicated. |
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Authors:
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W M Glazer; D S Charney; G R Heninger |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of general psychiatry Volume: 44 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-10-26 Completed Date: 1987-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 898-904 Citation Subset: AIM; IM |
Affiliation:
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Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arousal / drug effects Blood Pressure / drug effects Dopamine / physiology Dyskinesia, Drug-Induced / blood, physiopathology Female Humans Male Methoxyhydroxyphenylglycol / blood Middle Aged Norepinephrine / physiology* Psychiatric Status Rating Scales Pulse / drug effects Schizophrenia / blood, diagnosis, physiopathology* Schizophrenic Psychology Yohimbine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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MH30929/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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146-48-5/Yohimbine; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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