Document Detail

Noradrenergic function in schizophrenia.
MedLine Citation:
PMID:  3662745     Owner:  NLM     Status:  MEDLINE    
Yohimbine, an alpha 2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 16 healthy subjects and 18 drug-free schizophrenic patients with (n = 10) and without (n = 8) tardive dyskinesia (TD). Outcome measures of this double-blind, placebo-controlled study included changes in behavior, plasma 3-methoxy-4-hydroxy-phenylglycol (MHPG) level, blood pressure, and heart rate. A subgroup of six patients experienced a notable dysphoric arousal reaction that occurred 60 to 90 minutes following administration of 20 mg of yohimbine, this reaction was not observed in healthy subjects. The schizophrenic group as a whole (not the subgroup) showed a statistical trend toward a greater yohimbine-induced increase in plasma MHPG level and systolic sitting blood pressure. The patients with TD did not differ from those without TD or from healthy controls in their response to yohimbine. These results do not support the hypothesis that noradrenergic dysfunction plays a strong central role in the pathogenesis of schizophrenia or TD. However, further studies of noradrenergic dysfunction in sub-groups of patients with schizophrenia are indicated.
W M Glazer; D S Charney; G R Heninger
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  44     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-10-26     Completed Date:  1987-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-904     Citation Subset:  AIM; IM    
Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven.
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MeSH Terms
Arousal / drug effects
Blood Pressure / drug effects
Dopamine / physiology
Dyskinesia, Drug-Induced / blood,  physiopathology
Methoxyhydroxyphenylglycol / blood
Middle Aged
Norepinephrine / physiology*
Psychiatric Status Rating Scales
Pulse / drug effects
Schizophrenia / blood,  diagnosis,  physiopathology*
Schizophrenic Psychology
Yohimbine / pharmacology
Grant Support
Reg. No./Substance:
146-48-5/Yohimbine; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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